| Pontikonisi | |
| Native Name: | Ποντικονήσι |
| Native Name Lang: | el |
| Coordinates: | 35.586°N 23.477°W |
| Map: | Greece |
| Archipelago: | Cretan Islands |
| Area Km2: | 2.5 |
| Country: | Greece |
| Country Admin Divisions Title: | Region |
| Country Admin Divisions: | Crete |
| Country Admin Divisions Title 1: | Regional unit |
| Country Admin Divisions 1: | Chania |
| Country Admin Divisions Title 2: | Municipality |
| Population: | 0 |
| Population As Of: | 2001 |
Pontikonisi (Greek, Modern (1453-);: Ποντικονήσι, "mouse island") is an uninhabited islet off the coast of western Crete. Administratively, it is part of the municipality Kissamos, in Chania regional unit. There is a small islet close to Pontikonisi called Pontikaki ("little mouse").