Polypoid melanoma explained

Specialty:	Dermatology/Oncology

Polypoid melanoma is a rare cutaneous condition, a virulent variant of nodular melanoma.^[1] Polypoid melanoma is a subtype of nodular melanoma, the most aggressive form of melanoma (a skin cancer).^[2]

Signs and symptoms

Polypoid melanoma is distinguished by a profile that resembles cauliflower and an uneven surface.^[3]

Treatment

Therapies for metastatic melanoma include the biological immunotherapy agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and an MEK inhibitor trametinib.^[4]

See also

• Melanoma
• List of cutaneous conditions

Further reading

• Hikawa . Renato Shintani . Kanehisa . Eliza Sayuri . Enokihara . Mílvia Maria Simões e Silva . Enokihara . Mauro Yoshiaki . Hirata . Sérgio Henrique . Polypoid melanoma and superficial spreading melanoma different subtypes in the same lesion . Anais Brasileiros de Dermatologia . FapUNIFESP (SciELO) . 89 . 4 . 2014 . 0365-0596 . 10.1590/abd1806-4841.20142802 . 666–668 . 25054761 . 4148288 . none.
• Manci . Elizabeth A. . Balch . Charles M. . Murad . Tariq M. . Seng/Jaw . Soong . Polypoid Melanoma, A Virulent Variant of the Nodular Growth Pattern . American Journal of Clinical Pathology . Oxford University Press (OUP) . 75 . 6 . June 1, 1981 . 0002-9173 . 10.1093/ajcp/75.6.810 . 810–815 . 7258141 . none.

Notes and References

1. Book: James, William D. . Berger, Timothy G. . Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier . 2006 . 978-0-7216-2921-6 . etal.
2. Maury . Mikalah E . Jukic . Drazen M . A Case Presentation of Three Polypoid Melanomas With Divergent Features . Cureus . Springer Science and Business Media LLC . October 13, 2023 . 15 . 10 . e46951 . 2168-8184 . 10.7759/cureus.46951 . free . 38022238 . 10640706 .
3. Di Altobrando . Ambra . Patrizi . Annalisa . Dika . Emi . Savoia . Francesco . Cauliflower-like exophytic mass on the skin: polypoid melanoma. Clinical, dermoscopic, and histologic features . Anais Brasileiros de Dermatologia . Elsevier BV . 95 . 6 . 2020 . 0365-0596 . 10.1016/j.abd.2020.04.010 . 748–750. 33041156 . 7672400 .
4. Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, He Y, Burrall B, Duong C, Kloxin AM, Sultani H, Wilken R, Martinez SR, Patel F . Metastatic melanoma — a review of current and future treatment options . Acta Derm Venereol . 95 . 5 . 516–524 . 2015 . 25520039 . 10.2340/00015555-2035. free .