Poly ICLC explained

Poly ICLC is an immunostimulant. It is polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers carboxymethylcellulose and polylysine. It is under trial for use in cancer.[1]

Poly I:C is a ligand for toll like receptor-3, which usually triggers on the structurally similar double-stranded RNA present in some viruses.[2]

External links

Notes and References

  1. Web site: Intervention Dynamic Trial Listing Page . National Cancer Institute . en . 13 June 2017.
  2. Zhu X, Nishimura F, Sasaki K, etal . Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models . Journal of Translational Medicine . 5 . 10 . 2007 . 17295916 . 10.1186/1479-5876-5-10 . 1802742 . free .

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