Polo kinase explained
| Polo kinase |
| Ec Number: | 2.7.11.21 |
In enzymology, a polo kinase is a kinase enzyme i.e. one that catalyzes the chemical reaction
ATP + a protein
ADP + a phosphoprotein
Thus, the two substrates of these enzymes are ATP and protein, whereas their two products are ADP and phosphoprotein.
These enzymes belong to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).
The systematic name of this [polo[-like] kinase] enzyme class is ATP:protein phosphotransferase (spindle-pole-dependent).
Examples and other names in common use include Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, and STK21.
These enzymes participate in 3 metabolic pathways: cell cycle, cell cycle - yeast, and progesterone-mediated oocyte maturation.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and .
References
- Llamazares, Moreira, Tavares. 1991 . polo encodes a protein kinase homolog required for mitosis in Drosophila . Genes Dev. . 5 . 2153 - 65 . 1660828 . 10.1101/gad.5.12a.2153 . 12A . etal. free .
- "Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila" 1993
- Golsteyn RM, Mundt KE, Fry AM, Nigg EA . 1995 . Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function . J. Cell Biol. . 129 . 1617 - 28 . 7790358 . 10.1083/jcb.129.6.1617 . 6 . 2291169 .
- Mulvihill DP, Hyams JS . 2002 . Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint . J. Cell Sci. . 115 . 3575 - 86 . 12186944 . 10.1242/jcs.00031 . Pt 18 . free .
- Ohkura H . 2003 . Phosphorylation: polo kinase joins an elite club . Curr. Biol. . 13 . R912 - 4 . 14654016 . 10.1016/j.cub.2003.11.012 . 23 . 12000886 . free .
