Polly Fordyce Explained

Polly Fordyce
Birth Place:Washington, DC, USA
Fields:Bioengineering
Workplaces:Stanford University
Alma Mater:University of Colorado Boulder, BS
Stanford University, PhD
Doctoral Advisor:Steven Block
Academic Advisors:Joseph DeRisi
Known For:High-throughput enzymology, biophysics, microfludiics
Awards:Eli Lilly Award in Biological Chemistry
National Science Foundation CAREER Award

Polly Fordyce is an Associate Professor of Genetics and Bioengineering and fellow of the ChEM-H Institute at Stanford University.[1] Her laboratory's research focuses on developing and applying new microfluidic platforms for quantitative, high-throughput biophysics and biochemistry and single-cell genomics.

Fordyce was born and raised in Washington, DC.[2]

Education

Fordyce double-majored in physics and biology at the University of Colorado Boulder, graduating in 2000. She then began a PhD in the lab of Steven Block at Stanford University, where she worked as part of a team that developed new microscopes for applying force to molecules and understanding how it affected their movements.[3] After receiving her PhD in 2007, she moved to UCSF to pursue postdoctoral research in Joseph DeRisi's laboratory developing high-throughput methods for the analysis of transcription factor interactions.[4] She has been a professor at Stanford since 2014.[2]

Research

Fordyce's lab develops approaches for high throughput quantitative biochemistry, biophysics, and single cell assays, using a variety of approaches including microfluidics.[5] One of her lab's accomplishments is the development of the method HT-MEK (High-Throughput Microfluidic Enzyme Kinetics),[6] which enables researchers to analyze the effects of thousands of mutations on an enzyme's activity in a single experiment.[7]

Awards

Notes and References

  1. Web site: Polly Fordyce - Stanford Medicine Profiles . med.stanford.edu.
  2. Web site: The beadnik: Polly Fordyce uses something tiny to do something big. med.stanford.edu.
  3. Lang MJ, Fordyce PM, Engh AM, Neuman KC, Block SM . Simultaneous, coincident optical trapping and single-molecule fluorescence . Nature Methods . 1 . 2 . 133–139 . November 2004 . 15782176 . 1483847 . 10.1038/nmeth714 .
  4. Fordyce PM, Gerber D, Tran D, Zheng J, Li H, DeRisi JL, Quake SR . De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis . Nature Biotechnology . 28 . 9 . 970–975 . September 2010 . 20802496 . 2937095 . 10.1038/nbt.1675 .
  5. Web site: The Fordyce Lab.
  6. Markin CJ, Mokhtari DA, Sunden F, Appel MJ, Akiva E, Longwell SA, Sabatti C, Herschlag D, Fordyce PM . 6 . Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics . Science . 373 . 6553 . eabf8761 . July 2021 . 34437092 . 8454890 . 10.1126/science.abf8761 .
  7. Reardon S . Single chip tests thousands of enzyme mutations at once . Nature . July 2021 . 34302155 . 10.1038/d41586-021-02034-3 . 236210249 .
  8. Web site: Five Stanford faculty receive NSF CAREER Award . 2 February 2022 .
  9. Web site: Professor Polly Fordyce – Division of Biological Chemistry . 2023-01-06 . en-US.