Pleurocidin Explained

Symbol:	Antimicrobial12
Antimicrobial12
Pfam:	PF08107
Interpro:	IPR012515
Tcdb:	1.C.62
Opm Family:	142
Opm Protein:	1z64

Pleurocidin is an antimicrobial peptide found in the mucus secreted by the skin of the winter flounder (Pleuronectes americanus). It exhibits broad-spectrum antimicrobial activity.^[1] Pleurocidin assumes an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defence.^[2]

Potential Applications

Pleurocidin has been noted for its potential use in food safety, in part due to its heat stable properties and clinically demonstrated effectiveness against common food-borne microorganisms.^[3]

Notes and References

1. Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications. Journal of Food Science. 2004-04-01. 1750-3841. FMS66–FMS71. 69. 3. 10.1111/j.1365-2621.2004.tb13373.x. en. O. J.. Burrowes. C.. Hadjicharalambous. G.. Diamond. Tung-Ching. Lee.
2. Cole AM, Weis P, Diamond G . Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder . J. Biol. Chem. . 272 . 18 . 12008–13 . May 1997 . 9115266 . 10.1074/jbc.272.18.12008. free .
3. Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications. Journal of Food Science. 2004-04-01. 1750-3841. FMS66–FMS71. 69. 3. 10.1111/j.1365-2621.2004.tb13373.x. en. O. J.. Burrowes. C.. Hadjicharalambous. G.. Diamond. Tung-Ching. Lee.