Plasmepsin I Explained

Plasmepsin I
Ec Number:3.4.23.38
Cas Number:180189-87-1

Plasmepsin I (aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.

Notes and References

  1. Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB . Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease . The Journal of Experimental Medicine . 173 . 4 . 961–9 . April 1991 . 2007860 . 2190804 . 10.1084/jem.173.4.961 .
  2. Francis SE, Gluzman IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE . Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase . The EMBO Journal . 13 . 2 . 306–17 . January 1994 . 8313875 . 394809 . 10.1002/j.1460-2075.1994.tb06263.x .
  3. Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE . Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway . The Journal of Clinical Investigation . 93 . 4 . 1602–8 . April 1994 . 8163662 . 294190 . 10.1172/JCI117140 .

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