Plakophilin-3 Explained

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.^{[1] [2]}

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.^[2]

Interactions

PKP3 has been shown to interact with:

• DSC3,
• DSG1,
• DSG2 and
• DSG3.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Bonné S, van Hengel J, Nollet F, Kools P, van Roy F . Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. . J. Cell Sci. . 112 . 14 . 2265–76 . 1999 . 10.1242/jcs.112.14.2265 . 10381383 . 1854/LU-113819 . free .
• Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H . Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. . J. Cell Sci. . 113 . 13 . 2471–83 . 2000 . 10.1242/jcs.113.13.2471 . 10852826 .
• Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F . Defining desmosomal plakophilin-3 interactions. . J. Cell Biol. . 161 . 2 . 403–16 . 2003 . 12707304 . 2172904 . 10.1083/jcb.200303036 .
• Papagerakis S, Shabana AH, Depondt J, Gehanno P, Forest N . Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters. . Hum. Pathol. . 34 . 6 . 565–72 . 2003 . 12827610 . 10.1016/S0046-8177(03)00174-6 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . free .
• Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke WW . Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. . Mol. Biol. Cell . 17 . 3 . 1388–98 . 2006 . 16407409 . 1382326 . 10.1091/mbc.E05-08-0708 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonné S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A . The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. . FEBS Lett. . 581 . 8 . 1617–24 . 2007 . 17391671 . 2938730 . 10.1016/j.febslet.2007.03.026 .

Notes and References

1. Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW . Plakophilin 3--a novel cell-type-specific desmosomal plaque protein . Differentiation . 64 . 5 . 291–306 . Jun 1999 . 10374265 . 10.1046/j.1432-0436.1999.6450291.x .
2. Web site: Entrez Gene: PKP3 plakophilin 3.
3. Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F . Defining desmosomal plakophilin-3 interactions . J. Cell Biol. . 161 . 2 . 403–16 . Apr 2003 . 12707304 . 2172904 . 10.1083/jcb.200303036 . 1854/LU-210987 .