Plakophilin Explained

Plakophilin are proteins of the cytoskeleton. They are involved in regulating the adhesive activity of cadherin.^[1]

The three types of plakophilin proteins found in humans are PKP1, PKP2, and PKP3; all exhibiting dual localization in the nucleus as well as desmosomes.^{[2] [3]}

Genes include:

• PKP1
• PKP2
• PKP3

See also

• List of conditions caused by problems with junctional proteins

Notes and References

1. Kline CF, Mohler PJ . Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes . Current Topics in Membranes . 72 . 121–58 . 2013-01-01 . 24210429 . 10.1016/b978-0-12-417027-8.00004-0 . 2020-10-22 . Academic Press . Functional Organization of Vertebrate Plasma Membrane . Bennett V .
2. Book: Encyclopedia of Cancer . Springer, Berlin, Heidelberg . 978-3-642-16483-5 . 252 . 2011 . 10.1007/978-3-642-16483-5 . 2011 . 27502611 . Schwab M .
3. Miller RK, Hong JY, Muñoz WA, McCrea PD . Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling . Progress in Molecular Biology and Translational Science . 116 . 387–407 . January 2013 . 23481204 . 3752792 . 10.1016/b978-0-12-394311-8.00017-0 . Academic Press . The Molecular Biology of Cadherins . van Roy F .