| Piz Sena | |
| Other Name: | Vetta Sperella |
| Elevation M: | 3075 |
| Prominence M: | 344 |
| Prominence Ref: | [1] |
| Parent Peak: | Cima Viola |
| Range: | Livigno Alps |
| Location: | Lombardy, Italy/Graubünden, Switzerland |
| Map: | Alps |
| Coordinates: | 46.3533°N 10.1097°W |
| Listing: | Alpine mountains above 3000 m |
Piz Sena (also known as Vetta Sperella) is a mountain of the Livigno Alps, located on the border between Italy and Switzerland. On its (Swiss) western side it overlooks Poschiavo.