Pitrazepin Explained

Pitrazepin is a competitive GABA_A and glycine receptor antagonist.^{[1] [2] [3]} It has been used to study insect and snail nervous systems in scientific research.^{[4] [5] [6] [7] [8] [9]}

See also

• Bicuculline
• Strychnine

Notes and References

1. Gähwiler BH, Maurer R, Wüthrich HJ . Pitrazepin, a novel GABAA antagonist . Neuroscience Letters . 45 . 3 . 311–6 . April 1984 . 6328380 . 10.1016/0304-3940(84)90244-1. 45153546 .
2. Braestrup C, Nielsen M . Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors . European Journal of Pharmacology . 118 . 1–2 . 115–21 . November 1985 . 3002806 . 10.1016/0014-2999(85)90669-7.
3. Curtis DR, Gynther BD . Pitrazepin: a central glycine and GABA antagonist . European Journal of Pharmacology . 131 . 2–3 . 311–3 . November 1986 . 3816960 . 10.1016/0014-2999(86)90590-X.
4. Anthony NM, Harrison JB, Sattelle DB . GABA receptor molecules of insects . Exs . 63 . 172–209 . 1993 . 7678525 . 10.1007/978-3-0348-7265-2_8. 978-3-0348-7267-6 .
5. Sattelle DB, Pinnock RD, Wafford KA, David JA . GABA receptors on the cell-body membrane of an identified insect motor neuron . . 232 . 1269 . 443–56 . January 1988 . 2451252 . 10.1098/rspb.1988.0006. 1988RSPSB.232..443S . 40290279 .
6. Murphy VF, Wann KT . The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria . . 95 . 3 . 713–22 . November 1988 . 2850061 . 1854212 . 10.1111/j.1476-5381.1988.tb11697.x.
7. Zhang W, Han XY, Wong SM, Takeuchi H . Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron . General Pharmacology . 28 . 1 . 45–53 . January 1997 . 9112076 . 10.1016/S0306-3623(96)00152-8.
8. Kim KH, Takeuchi H . Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones . European Journal of Pharmacology . 182 . 1 . 49–62 . June 1990 . 2169426 . 10.1016/0014-2999(90)90492-O.
9. Takeuchi H . Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters . Comparative Biochemistry and Physiology C . 103 . 1 . 1–12 . September 1992 . 1360362 . 10.1016/0742-8413(92)90219-w.