Piscarinine Explained

thumb|150px|2D Structure of Piscarinine A and Piscarinine B

Piscarinines are bioactive alkaloid isolates of Penicillium piscarium NKM F-961 [1] and Penicillium piscarium Westling [2] that belong to a class of naturally occurring 2,5-diketopiperazines.[3] The cytotoxic dehydroproline tryptophan derivatives piscarinines A and B were shown to be active against the prostate cancer cell line LNCAP (IC50 values were 2.2 and 1.9 μg/mL for piscarinine A and B, respectively).

Notes and References

  1. Piscarinines, new polycyclic diketopiperazine alkaloids from Penicillium piscarium NKM F-691 . Kozlovsky A, Vinokurova NG, Adanin VM, Gräfe U . Natural Product Letters . September 2000 . 14 . 5 . 333–340. 10.1080/10575630008043765.
  2. Zhelifonova VP, Maier A, Kozlovskii AG . Effect of various factors on the biosynthesis of piscarinines, secondary metabolites of the fungus Penicillium piscarium Westling . Applied Biochemistry and Microbiology . 44 . 6 . 608–612 . November 2008 . 19145974 . 10.1134/S0003683808060082 .
  3. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products . Borthwick AD . Chemical Reviews . May 2012 . 112 . 7 . 3641–3716 . 10.1021/cr200398y . 22575049.

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