| Native Name: | Departamento de Pisagua |
| Conventional Long Name: | Pisagua Department |
| Common Name: | Pisagua Department |
| Subdivision: | Department |
| Nation: | Chile |
| Demonym: | Pisagüino |
| Capital: | Pisagua (1884-1970) Huara (1970-1979) |
| Today: | Chile |
| Year Start: | 1884 |
| Year End: | 1974 |
| Date Start: | 31 October |
| Date End: | July |
| Era: | War of the Pacific aftermath |
| Flag: | Flag of Chile |
| Image Map Caption: | Map of Tarapacá Province (1895) |
| P1: | Tarapacá Department (Peru)Tarapacá Department |
| Flag P1: | Flag of Peru (1822-1825).svg |
| S1: | Tamarugal Province |
| Flag S1: | Flag of Chile.svg |
Pisagua Department was a department in Tarapacá Province, Chile, from 1883 to 1974. It was ceded to Chile under the Treaty of Ancón, formerly being part of the Peruvian province of the same name.
The department was created on 31 October 1884 under the administration of the also new Tarapacá Province, both awarded to Chile under the Treaty of Ancón, along with Tacna. It was bordered to the north by the Arica Department, to the east by Bolivia, to the south by the Tarapacá Department (after 1928 the Iquique Department), and to the west by the Pacific Ocean.