Pirprofen Explained

Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID)^[1] that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis and pain. Its label was restricted after adverse events arose, including some cases of fatal liver toxicity.^[2] Ciba-Geigy voluntarily withdrew the drug from the market worldwide in 1990.^[3]

Notes and References

1. Todd PA, Beresford R . Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy . Drugs . 32 . 6 . 509–37 . December 1986 . 3539573 . 10.2165/00003495-198632060-00003 . 195692709 .
2. Depla AC, Vermeersch PH, van Gorp LH, Nadorp JH . Fatal acute liver failure associated with pirprofen. Report of a case and a review of the literature . The Netherlands Journal of Medicine . 37 . 1–2 . 32–6 . August 1990 . 2215831 .
3. WHO. Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue - Pharmaceuticals. United Nations - New York, 2005