Piroheptine Explained

Piroheptine (brand name Trimol) is an anticholinergic and antihistamine used as an antiparkinsonian agent.

Piroheptine was observed to prevent the reuptake of dopamine and is therefore a DRI.^{[1] [2]}

Piroheptine comes from a family of drugs that includes pridefine and etifelmine.

Notes and References

1. Saitoh T . Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl . Journal of the Neurological Sciences . 83 . 2–3 . 161–166 . February 1988 . 3258627 . 10.1016/0022-510X(88)90065-2 . 25230405 .
2. Ohashi T, Akita H, Tamura T, Noda K, Honda F . Effect of piroheptine, a new antiparkinson drug, on dopamine uptake into synaptosomes from corpus striatum of rat brain . Arzneimittel-Forschung . 22 . 6 . 966–972 . June 1972 . 5068358 .