Piretanide Explained

Piretanide is a loop diuretic^[1] compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. Studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. These findings led eventually to studies in man and finally to the introduction as a saluretic and antihypertensive^[2] medication in Germany, France, Italy and other countries.

It was made in 1973, patented in 1974, and approved for medical use in 1981.^[3]

Brand names

Brand names include Arelix, Eurelix, Tauliz.

Further reading

• Merkel W, Bormann D, Mania D, Muschaweck R, Hropot M . Piretanide (HOE118): A new high-ceiling sali-diuretic . European Journal of Medicinal Chemistry . 11 . 399 . 1976 .
• Merkel W, Mania D, Bormann D . Selektive Reduktion von Imiden mit funktionellen Gruppen . Selective reduction of imides in the presence of other function groups . German . Liebigs Annalen der Chemie . 1979 . 4 . 461–9 . 1979 . 10.1002/jlac.197919790406 .

Notes and References

1. Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD . Blood pressure-lowering efficacy of loop diuretics for primary hypertension . The Cochrane Database of Systematic Reviews . 2015 . 5 . CD003825 . May 2015 . 26000442 . 7156893 . 10.1002/14651858.CD003825.pub4 .
2. Book: Austria-Codex. Haberfeld H. Österreichischer Apothekerverlag. Vienna. 2009. 2009/2010. 978-3-85200-196-8. German.
3. Book: Fischer J, Ganellin CR . Analogue-based Drug Discovery . 2006 . John Wiley & Sons . 9783527607495 . 458 . en.