Pirenperone Explained

Pirenperone (; developmental code names R-47456, R-50656) is a serotonin receptor antagonist described as an antipsychotic and tranquilizer which was never marketed.^{[1] [2]} It is a relatively selective antagonist of the serotonin 5-HT₂ receptors and has been used in scientific research to study the serotonin system.^[3] In the 1980s, the drug was found to block the effects of the lysergic acid diethylamide (LSD) in animals, and along with ketanserin, led to the elucidation of the 5-HT_2A receptor as the biological mediator of the effects of serotonergic psychedelics.^[4]

See also

• Altanserin
• Ketanserin
• Setoperone
• Risperidone
• Ocaperidone

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 994–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 31 October 1999. Springer Science & Business Media. 978-0-7514-0499-9. 223–.
3. Book: Colpaert FC, Balster R . Transduction Mechanisms of Drug Stimuli. 6 December 2012. Springer Science & Business Media. 978-3-642-73223-2. 29–.
4. Nichols DE . Psychedelics . Pharmacological Reviews . 68 . 2 . 264–355 . April 2016 . 26841800 . 4813425 . 10.1124/pr.115.011478 .