Piperidione Explained

Piperidione (trade name Sedulon) is a sedative drug, structurally related to methyprylon and pyrithyldione.It used to be marketed by Roche as a cough medicine available in liquid form.[1] [2] [3] In the US, it was approved by the FDA on grounds of safety alone in 1947. After Roche failed to submit evidence of efficacy to the Drug Efficacy Study Implementation program in 1972, it was withdrawn from the US market.[4]

See also

Notes and References

  1. Wolff PO . On pethidine and methadone derivatives . Bulletin of the World Health Organization . 2 . 2 . 193–204 . 1949 . 15409516 . 2553950 .
  2. Jacobs S . The use of piperidione as a cough sedative . Medical Times . 76 . 10 . 445–7 . October 1948 . 18102053 .
  3. Rimoldi R, Fioretti M, Bandella M . [Use of an antitussive drug in pulmonary pathology] . Bollettino Chimico Farmaceutico . 124 . 2 . 1S–6S . February 1985 . 3839404 .
  4. Certain Preparations Containing Dihyprylone or Pipazethate Hydrochloride; Notice of Withdrawal of Approval of New-Drug Applications. FDC–D–458 . August 5, 1972 . Federal Register . 37 . 152 . 15887 .

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