Piper hederaceum, also known as the giant pepper vine, is a vine in the pepper family Piperaceae. It is endemic to eastern Australia, growing in rainforests from Lockhart River, Queensland to Bermagui, New South Wales.
This species was first described in 1845 by the Dutch botanist Friedrich Anton Wilhelm Miquel, who gave it the combination Cubeba hederacea and published his description in The London Journal of Botany. It was subsequently transferred to Piper hederaceum in 1869 by the Swiss botanist Anne Casimir Pyramus de Candolle, writing in the book Prodromus Systematis Naturalis Regni Vegetabilis.