| Pine Run | |
| Name Other: | Tributary to Neshannock Creek |
| Map Size: | 300 |
| Pushpin Map: | USA Pennsylvania#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Pine Run mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States of America |
| Subdivision Type2: | State |
| Subdivision Name2: | Pennsylvania |
| Subdivision Type3: | County |
| Subdivision Name3: | Mercer |
| Subdivision Type4: | Townships |
| Subdivision Name4: | Springfield Findley |
| Length: | 5.08miles[1] |
| Discharge1 Avg: | 13.31cuft/s at mouth with Neshannock Creek[2] |
| Source1: | divide between Pine Run and Wolf Creek (Barmore Run) |
| Source1 Location: | about 2 miles northeast of Blacktown, Pennsylvania |
| Source1 Coordinates: | 41.1794°N -80.1478°W[3] |
| Source1 Elevation: | 1280feet[4] |
| Mouth: | Neshannock Creek |
| Mouth Location: | about 1 mile northeast of Millburn, Pennsylvania |
| Mouth Coordinates: | 41.1781°N -80.225°W |
| Mouth Elevation: | 1060feet |
| Progression: | Neshannock Creek → Shenango River → Beaver River → Ohio River → Mississippi River → Gulf of Mexico |
| River System: | Beaver River |
| Tributaries Left: | unnamed tributaries |
| Tributaries Right: | unnamed tributaries |
Pine Run is a tributary to Neshannock Creek in western Pennsylvania. The stream rises in southeastern Mercer County and flows west entering Neshannock Creek south and downstream of Mercer, Pennsylvania. The watershed is roughly 41% agricultural, 50% forested and the rest is other uses.[2]