Pildralazine Explained

Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.^[1]

Synthesis

The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).

Notes and References

1. Book: Ganellin CR, Triggle DJ, Macdonald F . Dictionary of pharmacological agents . 25 November 2011 . 1997 . CRC Press . 978-0-412-46630-4 . 1603.