| Pignataro Interamna | |
| Official Name: | Comune di Pignataro Interamna |
| Coordinates: | 41.4333°N 60°W |
| Region: | Lazio |
| Province: | Frosinone (FR) |
| Mayor: | Benedetto Murro |
| Area Total Km2: | 24.41 |
| Population Total: | 2500 |
| Population As Of: | 31 October 2019 |
| Population Demonym: | Pignataresi |
| Elevation M: | 64 |
| Postal Code: | 03040 |
| Area Code: | 0776 |
Pignataro Interamna is a town and comune in the province of Frosinone, Lazio, Italy. It takes its name from the ancient Latin colony of Interamna Lirenas, founded by the Romans after the conquest of Casinum, an ancient Oscan city. The town is in the southernmost part of the province of Frosinone.