Nicolas Pierre-Jules Delespine (31 October 1756, Paris – 16 September 1825, Paris) was a French architect.
He came from a long line of architects, which included his father, Louis-Jules Delespine (1726-1796). After learning all he could at home, he continued his studies with Antoine-François Peyre and .
From 1800 until his death, he was a professor at the École des beaux-arts, and served as a member of the École's jury. His workshop enjoyed a high reputation. Several of his students were winners of the Prix de Rome for architecture: Félix Callet (1819), Abel Blouet (1821), (1828), and (1830)
He was a member of the Council for Civic Buildings and, in 1824, became a member of the Académie des Beaux-Arts. There, he took Seat #1 for architecture, succeeding Maximilien Joseph Hurtault, deceased.
In addition to his official work, he built hotels and inns on the Rue de Rivoli and the . He also worked on restorations at the Church of Saint-Roch and the .