Picornain 2A Explained

Picornain 2A
Ec Number:	3.4.22.29
Cas Number:	103406-62-8

Picornain 2A (picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A proteinase, Y-G proteinase 2A, poliovirus proteinase 2A, poliovirus protease 2Apro) is a protease enzyme.^{[1] [2] [3]} This enzyme catalyses selective cleavage of Tyr-Gly bond in picornavirus polyprotein.

This enzyme is coded by entero-, rhino-, aphto- and cardioviruses.

Notes and References

1. Bazan JF, Fletterick RJ . Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications . Proceedings of the National Academy of Sciences of the United States of America . 85 . 21 . 7872–6 . November 1988 . 3186696 . 282299 . 10.1073/pnas.85.21.7872 . 1988PNAS...85.7872B . free .
2. König H, Rosenwirth B . Purification and partial characterization of poliovirus protease 2A by means of a functional assay . Journal of Virology . 62 . 4 . 1243–50 . April 1988 . 10.1128/JVI.62.4.1243-1250.1988 . 2831385 . 253133 .
3. Kräusslich HG, Wimmer E . Viral proteinases . Annual Review of Biochemistry . 57 . 701–54 . 1988 . 3052288 . 10.1146/annurev.bi.57.070188.003413 .