Phospholysine phosphohistidine inorganic pyrophosphate phosphatase explained

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase is a protein that in humans is encoded by the LHPP gene.^[1]

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease . Am. J. Hum. Genet. . 78 . 1 . 78–88 . January 2006 . 16385451 . 1380225 . 10.1086/498851 .
• Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA . Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression . Mol. Psychiatry . 14 . 6 . 621–30 . June 2009 . 18268499 . 10.1038/mp.2008.8 . free .
• Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA . Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression . Mol. Psychiatry . 14 . 6 . 621–30 . June 2009 . 18268499 . 10.1038/mp.2008.8 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J . The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene . Neuropsychopharmacology . 42 . 3 . 598–605 . February 2017 . 27531626 . 5240175 . 10.1038/npp.2016.153 .
• Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dąbrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P . Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer . Nat. Genet. . 48 . 12 . 1544–1550 . December 2016 . 27749845 . 5131845 . 10.1038/ng.3685 .

Notes and References

1. Web site: Entrez Gene: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase. 2018-07-14.