PHLDB2 explained

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.^{[1] [2]}

Interactions

PHLDB2 has been shown to interact with FLNC.

Further reading

• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR . Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities . Biochem. J. . 351 . Pt 1 . 19–31 . October 2000 . 11001876 . 1221362 . 10.1042/0264-6021:3510019 .
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A . CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta . Dev. Cell . 11 . 1 . 21–32 . July 2006 . 16824950 . 10.1016/j.devcel.2006.05.012 . free .
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y . Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta . J. Cell Biol. . 189 . 5 . 901–17 . May 2010 . 20513769 . 2878951 . 10.1083/jcb.200910095 .

Notes and References

1. Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L . LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin . J Biol Chem . 278 . 2 . 1328–35 . Jan 2003 . 12376540 . 10.1074/jbc.M208352200 . free .
2. Web site: Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2.