Philip Awadalla Explained

Philip Awadalla
Birth Name:Philip Awadalla
Birth Date:7 November 1969
Birth Place:Canada
Thesis Year:2001
Doctoral Advisor:Deborah Charlesworth

Philip Awadalla is a professor of medical and population genetics at the Ontario Institute for Cancer Research, and the Department of Molecular Genetics, Faculty of Medicine, University of Toronto. He is the National Scientific Director[1] [2] of the Canadian Partnership for Tomorrow's Health (CanPath), formerly the Canadian Partnership for Tomorrow Project (CPTP),[3] [4] and executive director of the Ontario Health Study.[5] He is also the Executive Scientific Director of the Genome Canada Genome Technology Platform, the Canadian Data Integration Centre.[6] [7] Professor Awadalla was the Executive Scientific Director of the CARTaGENE biobank,[8] [9] [10] a regional cohort member of the CPTP, from 2009 to 2015, and is currently a scientific advisor for this and other scientific and industry platforms. At the OICR, he is Director of Computational Biology.

Career

Philip Awadalla completed his Ph.D at the University of Edinburgh, Scotland under the supervision of Deborah Charlesworth in 2001. He then completed a Killam Trust Fellowship and Wellcome Trust postdoctoral fellowships under the supervision of Sarah Otto at the University of British Columbia (2001) and Charles Langley at the University of California, Davis (US) (2001-2003).

In 2004, Awadalla was appointed as assistant professor at the Department of Genetics and Centre for Bioinformatics (led by Bruce Weir) at North Carolina State University. His work there included identifying potential genetic targets for vaccines to Plasmodium falciparum, the main malaria parasite.[11] [12] This has included the first genetic maps and mapping of drug resistance genes in malaria.[13] [14]

In 2007 Awadalla, he became an associate professor in the department of pediatrics at the Université de Montréal, and in 2009 he became the Executive Scientific Director of the CARTaGENE Biobank of Québec. His research focused on developing next-generation genomics platforms to support to pediatric disease research and discovery of rare mutations.[15] Awadalla discovered the relationship of a histone methylating factor encoded by the gene PRDM9 and child-hood acute lymphoblastic leukemia.[16] [17]

Research by Awadalla (with Matthew Hurles of the Wellcome Trust Sanger Institute) was first to directly estimate the number of mutations passed on by individual parents to human offspring, fewer than was previously estimated.[18] [19] Other discoveries include large scale RNA methylation and its genetic control in human mitochondria[20] and the impact of population size on negative selection in humans.[21] [22] The Awadalla team were also the first to show the impact of air pollution on gene expression and disease among thousands of individuals in the Quebec population.[23] [24]

Awadalla is part of a number of collaborative programmes, including the analysis and functional analysis groups of the 1000 Genomes Project[25] and the Pan Cancer Analysis of Whole Genomes Program.

External links

Notes and References

  1. Web site: Canada's largest health research platform teams up with University of Toronto to accelerate cancer and chronic disease research. www.newswire.ca. en. 2018-07-22.
  2. Web site: U of T selected as scientific partner of Canada's largest health research platform to accelerate cancer and chronic disease research. www.dlsph.utoronto.ca. 11 April 2018. en-US. 2018-07-22.
  3. Web site: Home . partnershipfortomorrow.ca.
  4. Dummer. Trevor J. B.. Awadalla. Philip. Boileau. Catherine. Craig. Camille. Fortier. Isabel. Goel. Vivek. Hicks. Jason M. T.. Jacquemont. Sébastien. Knoppers. Bartha Maria. 2018-06-11. The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention. CMAJ. en. 190. 23. E710–E717. 10.1503/cmaj.170292. 0820-3946. 5995593. 29891475.
  5. Web site: Home . ontariohealthstudy.ca.
  6. Web site: Archived copy . 2015-10-20 . dead . https://web.archive.org/web/20150918225029/http://www.genomecanada.ca/medias/PDF/en/techno/Awadalla-Canadian-Data-Integration-Centre-CDIC.pdf . 2015-09-18 .
  7. News: The Canadian Data Integration Centre receives new funding to help cancer researchers translate findings to patients. 2018-01-25. OICR News. 2018-07-22. en-CA.
  8. Web site: Home . cartagene.qc.ca.
  9. Web site: Tranquillement, mais sûrement, l'ADN humain!. ICI.Radio-Canada.ca. Zone Aucun thème sélectionné -. Radio-Canada.ca. fr-ca. 2018-07-22.
  10. News: Quebec bio-bank project expands CBC News. CBC. 2018-07-22. en-US.
  11. Mu . J. . Awadalla . P. . Duan . J. . McGee . K. M. . Keebler . J. . Seydel . K. . McVean . G. A. T. . Su . X. Z. . 10.1038/ng1924 . Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome . Nature Genetics . 39 . 1 . 126–130 . 2006 . 17159981. 19949550 . free .
  12. News: Smith. Zach. NCSU evolutionary geneticist researches malaria's bite. Triangle Business Journal. 22 January 2007. 7 May 2013.
  13. Idaghdour. Y.. Quinlan. J.. Goulet. J. -P.. Berghout. J.. Gbeha. E.. Bruat. V.. De Malliard. T.. Grenier. J. -C.. Gomez. S.. 2012. Feature Article: Evidence for additive and interaction effects of host genotype and infection in malaria. Proceedings of the National Academy of Sciences. 109. 42. 16786–16793. 10.1073/pnas.1204945109. 3479498. 22949651. Gros. P.. Rahimy. M. C.. Sanni. A.. Awadalla. P.. free.
  14. Mu. Jianbing. etal. 2010. Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots. Nature Genetics. 42. 3. 268–271. 10.1038/ng.528. 2828519. 20101240.
  15. Awadalla. Philip. Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts. American Journal of Human Genetics. 2010. 87. 316–324. 2933353. 10.1016/j.ajhg.2010.07.019. 20797689. 3. etal.
  16. News: Smith. Zach. This Week in Genome Research. Genome Web. 26 December 2012. 7 May 2013.
  17. Hussin. Julie. Rare allelic forms of PRDM9 associated with childhood leukemia.. Genome Research. 2012. etal. 10.1101/gr.144188.112. 23. 3. 419–430. 23222848. 3589531.
  18. Conrad . D. F. . Keebler . J. E. M. . Depristo . M. A. . Lindsay . S. J. . Zhang . Y. . Casals . F. . Idaghdour . Y. . Hartl . C. L. . Torroja . C. . Garimella . 10.1038/ng.862 . K. V. . Zilversmit . M. . Cartwright . R. . Rouleau . G. A. . Daly . M. . Stone . E. A. . Hurles . M. E. . Awadalla . P. . 1000 Genomes . P. . Variation in genome-wide mutation rates within and between human families . Nature Genetics . 43 . 7 . 712–714 . 2011 . 21666693. 3322360 .
  19. Web site: Family Genetic Research Reveals the Speed of Human Mutation . . 13 June 2011 . Science Daily . 6 May 2013.
  20. Hodgkinson. Alan. Idaghdour. Youssef. Gbeha. Elias. Grenier. Jean-Christophe. Hip-Ki. Elodie. Bruat. Vanessa. Goulet. Jean-Philippe. Malliard. Thibault de. Awadalla. Philip. 2014-04-25. High-Resolution Genomic Analysis of Human Mitochondrial RNA Sequence Variation. Science. en. 344. 6182. 413–415. 10.1126/science.1251110. 0036-8075. 24763589. 2014Sci...344..413H. 30201335.
  21. Casals. Ferran. Hodgkinson. Alan. Hussin. Julie. Idaghdour. Youssef. Bruat. Vanessa. Maillard. Thibault de. Grenier. Jean-Cristophe. Gbeha. Elias. Hamdan. Fadi F.. 2013-09-26. Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans. PLOS Genetics. en. 9. 9. e1003815. 10.1371/journal.pgen.1003815. 1553-7404. 3784517. 24086152 . free .
  22. Hussin. Julie G. Hodgkinson. Alan. Idaghdour. Youssef. Grenier. Jean-Christophe. Goulet. Jean-Philippe. Gbeha. Elias. Hip-Ki. Elodie. Awadalla. Philip. 2015-02-16. Recombination affects accumulation of damaging and disease-associated mutations in human populations. Nature Genetics. En. 47. 4. 400–404. 10.1038/ng.3216. 25685891. 24804649. 1061-4036.
  23. Favé. Marie-Julie. Lamaze. Fabien C.. Soave. David. Hodgkinson. Alan. Gauvin. Héloïse. Bruat. Vanessa. Grenier. Jean-Christophe. Gbeha. Elias. Skead. Kimberly. 2018-03-06. Gene-by-environment interactions in urban populations modulate risk phenotypes. Nature Communications. En. 9. 1. 827. 10.1038/s41467-018-03202-2. 2041-1723. 5840419. 29511166. 2018NatCo...9..827F.
  24. News: Genetic study of Quebec residents finds air pollution trumps ancestry. Globe and Mail. 2018-07-22.
  25. 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes.. Nature. 491. 7422. 56–65. 10.1038/nature11632. 23128226. 3498066. 2012. 2012Natur.491...56T.

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