Phillip D. Zamore Explained

Phillip D. Zamore
Fields:Biochemistry, molecular biology
Workplaces:University of Massachusetts Chan Medical School, Howard Hughes Medical Institute
Alma Mater:Harvard University, Whitehead Institute
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Thesis2 Url:)-->The structure and function of the mammalian splicing factor U2AF
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Doctoral Advisors:)—>Michael R. Green
Academic Advisors:Michael Green, Ruth Lehmann, David Bartel, and James R. Williamson
Doctoral Students:Yukihide Tomari, Zhao Zhang, Elif Sarinay Cenik
Known For:small RNA biology and therapeutics
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Phillip D. Zamore is an American molecular biologist and biochemist who co-developed the first in vitro system for studying the mechanism of RNA interference (RNAi). He is the Gretchen Stone Cook Professor of Biomedical Sciences[1] at University of Massachusetts Chan Medical School, Worcester, Massachusetts. Zamore is chair of the RNA Therapeutics Institute (RTI), established in 2009, and has been a Howard Hughes Medical Institute Investigator since 2008.[2]  

Research

The Zamore lab seeks to understand the molecular mechanisms and biological functions of RNAi and related pathways in animals, including how small RNAs (microRNAs, small interfering RNAs, and PIWI-interacting RNAs) regulate gene expression and suppress transposons.[3] In addition to a focus on basic research, the Zamore lab is working to develop novel nucleic acid-based drugs to treat human disease. Dr. Zamore has more than 60,000 citations on Google Scholar.[4]

Biography

Zamore received his A.B. in biochemistry and molecular biology from Harvard University in Cambridge, Massachusetts, in 1986 and continued graduate studies with Michael Green at Harvard, receiving his Ph.D. in 1992. After completing postdoctoral studies at The Whitehead Institute for Biomedical Research, MIT, and the Skirball Institute at New York University Medical Center with Ruth Lehmann, James R. Williamson, and David Bartel, Zamore began his academic career as an assistant professor in the Department of Biochemistry and Molecular Pharmacology in 1999 at UMass Medical School in Worcester, Massachusetts. A member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences, Zamore has trained 40 PhD and MD/PhD students and post-doctoral scholars.

Involvement with biotechnology

Zamore's research has led to a career in biotechnology, co-founding Alnylam Pharmaceuticals in 2002.[5] Alnylam is dedicated to bringing RNAi based therapies to market and developed the first-ever FDA approved RNAi drug, Patisiran, gaining FDA approval in August 2018.[6] In 2014, Dr. Zamore co-founded another RNAi based company; Voyager Therapeutics,[7] which focuses on developing therapeutics for neurodegenerative disorders.

Selected awards and honors

Selected publications

Notes and References

  1. Web site: Phillip Zamore Profiles RNS. profiles.umassmed.edu. en. 2018-10-30.
  2. News: Phillip D. Zamore, PhD . HHMI.org. 2018-10-30. en.
  3. Web site: Phillip Zamore's Laboratory. Phillip Zamore's Laboratory. en. 2018-11-09.
  4. Web site: Phillip D. Zamore - Google Scholar Citations. scholar.google.com. 2018-10-30.
  5. Web site: Alnylam SAB.
  6. News: FDA approval of Alnylam drug is first ever for RNAi-based therapy - STAT. 2018-08-10. STAT. 2018-10-30. en-US.
  7. Web site: Founders . Voyager Therapeutics . 2018-10-30.
  8. Web site: October 9, 2023 . National Academy of Medicine Elects 100 New Members .
  9. Web site: 2023 NAS Election . 2023-05-09 . www.nasonline.org.
  10. Web site: New Members . 2023-05-01 . American Academy of Arts & Sciences . en.
  11. News: Paper of the Year - Oligonucleotide Therapeutics Society. Oligonucleotide Therapeutics Society. 2018-10-30. en-US.
  12. Web site: Chancellor's Medals. 2014-03-31. University of Massachusetts Medical School. en-US. 2018-10-30.
  13. News: Three UMMS scientists named in 2014 Thomson Reuters Report on most influential scientific minds. 2014-07-10. University of Massachusetts Medical School. 2018-10-30. en-US.
  14. 10.1038/bioe.2015.9 . Top 20 translational researchers of 2014 . Bioentrepreneur . 2015 . Huggett . Brady . Paisner . Kathryn . 33 . 9 . 897 . 26349903 . free .
  15. Web site: Search Fellows - National Academy of Inventors. academyofinventors.org. en. 2018-10-30.
  16. Web site: Phillip D. Zamore, Ph.D.. www.pewtrusts.org. 2018-11-09.

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