Phenylsilatrane Explained

Phenylsilatrane is a convulsant chemical which has been used as a rodenticide.^{[1] [2]} Phenylsilatrane and some of its analogs with 4-substituents of H, CH₃, Cl, Br, and CSi(CH₃)₃ are highly toxic to mice. They have been observed in the laboratory to inhibit the ³⁵S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.^[3]

See also

• Atrane
• GABA_A receptor negative allosteric modulator
• GABA_A receptor § Ligands
• Chlorophenylsilatrane

Notes and References

1. Voronkov MG . Silatranes: Intra-Complex Heterocyclic Compounds of Pentacoordinated Silicon . Pure and Applied Chemistry . 1966 . 13 . 1–2 . 35–60 . 10.1351/pac196613010035 . pdf .
2. Lukevics E, Ignatovich L, Khokhlova L, Belyakov S . Synthesis, Structure, and Toxicity of Arylgermatranes . Chemistry of Heterocyclic Compounds . 1997 . 33 . 2 . 239–241 . 10.1007/BF02256767 .
3. Horsham MA, Palmer CJ, Cole LM, Casida JE . 4-Alkynylphenylsilatranes: Insecticidal Activity, Mammalian Toxicity, and Mode of Action . Journal of Agricultural and Food Chemistry . 1990 . 38 . 8 . 1734–1738 . 10.1021/jf00098a023 .