Phenylethylidenehydrazine Explained

Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is a GABA transaminase inhibitor.[1] [2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH may contribute to phenelzine's anxiolytic effects.[3]

See also

Notes and References

  1. Parent MB, Master S, Kashlub S, Baker GB . Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum . . 63 . 1 . 57–64 . January 2002 . 11754874 . 10.1016/S0006-2952(01)00856-5.
  2. Duffy S, Nguyen PV, Baker GB . Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices . Neuroscience . 126 . 2 . 423–432 . 2004 . 15207360 . 10.1016/j.neuroscience.2004.03.007 . 30625470.
  3. Baker GB, Wong JT, Yeung JM, Coutts RT . March 1991 . Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA) . Journal of Affective Disorders . 21 . 3 . 207–211 . 10.1016/0165-0327(91)90041-p . 0165-0327 . 1648582.

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