Phenylacetate—CoA ligase explained

Phenylacetate—CoA ligase
Ec Number:	6.2.1.30
Cas Number:	57219-71-3
Go Code:	0047475

In enzymology, a phenylacetate—CoA ligase is an enzyme that catalyzes the chemical reaction

ATP + phenylacetate + CoA

\rightleftharpoons AMP + diphosphate + phenylacetyl-CoA

The 3 substrates of this enzyme are ATP, phenylacetate, and CoA. Its 3 products are AMP, diphosphate, and phenylacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is phenylacetate:CoA ligase (AMP-forming). Other names in common use include phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

References

• Martinez-Blanco H, Reglero A, Rodriguez-Aparicio LB, Luengo JM . 1990 . Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid . J. Biol. Chem. . 265 . 7084 - 90 . 2324116 . 12 .