Phenpromethamine Explained

Phenpromethamine (former brand name Vonedrine), also known as N,β-dimethylphenethylamine, is a sympathomimetic nasal decongestant of the phenethylamine group.^{[1] [2] [3] [4]} It was previously marketed as a nasal inhaler from 1943 through 1960 but is no longer available.^[5] The medication is a stimulant and is banned by the World Anti-Doping Agency.^[6] It has been detected in dietary supplements starting in the 2010s.

See also

• β-Methylphenethylamine
• Methamphetamine
• N-Methylphenethylamine

Notes and References

1. Weston AW, Ruddy AW, Suter CM . The Condensation of Unsaturated Amines with Aromatic Compounds. The Preparation of β-Substituted Phenethylamines . Journal of the American Chemical Society . 65 . 4 . 1943 . 674–677 . 0002-7863 . 10.1021/ja01244a049.
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . 14 November 2014 . Springer . 978-1-4757-2085-3 . 971–.
3. Docherty JR . Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA) . British Journal of Pharmacology . 154 . 3 . 606–22 . June 2008 . 18500382 . 2439527 . 10.1038/bjp.2008.124 .
4. Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ . Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine . Clinical Toxicology . 975–981 . March 2021 . 59 . 11 . 33755516 . 10.1080/15563650.2021.1894333 . 232338883 .
5. Tsumura Y, Kiguchi A, Komatsuzaki S, Ieuji K . A novel method to distinguish β-methylphenylethylamines from isomeric α-methylphenylethylamines by liquid chromatography coupled to electrospray ionization mass spectrometry . Forensic Toxicology . 38 . 2 . 2019 . 465–474 . 1860-8965 . 10.1007/s11419-019-00511-z . 212828763. free .
6. Web site: The 2006 WADA Prohibited List: Summary of Revisions . 2006 Canadian Centre for Ethics in Sport Advisory Notice . https://web.archive.org/web/20070411170302/http://www.cces.ca/pdfs/CCES-ADV-2006ListUpdate-E.pdf . 11 April 2007.