Phenethyl isothiocyanate explained

Phenethyl isothiocyanate (PEITC) is a naturally occurring isothiocyanate whose precursor, gluconasturtiin is found in some cruciferous vegetables,[1] especially watercress.

PEITC has been studied for its potential for chemoprevention of cancers,[2] [3] such as prostate cancer.[4]

In terms of biosynthesis, PEITC is produced from gluconasturtiin by the action of the enzyme myrosinase.

Notes and References

  1. Web site: Dictionary of Cancer Terms: PEITC . National Cancer Institute.
  2. 20013083 . 2010 . Cheung . KL . Kong . AN . Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention . 12 . 1 . 87–97 . 10.1208/s12248-009-9162-8 . 2811646 . The AAPS Journal.
  3. Kwon, Ki Han . Xu, Changjiang . Keum, Young-Sam . Khor, Tin Oo . Kim, Jung-Hwan . Huang, Mou-Tuan . Reddy, Bandaru S. . Li, Wenge . Kong, Ah-Ng Tony . Natural dietary phytochemicals: a promising future for cancer prevention and treatment of earlier lesion . Cancer: Disease Progression and Chemoprevention . 2007 . 109–126.
  4. 20664922 . 2010 . Wang . LG . Chiao . JW . Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review) . 37 . 3 . 533–9 . . 10.3892/ijo_00000702. free .

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