| Official Name: | Phayakkhaphum Phisai |
| Native Name: | พยัคฆภูมิพิสัย |
| Native Name Lang: | th |
| Settlement Type: | District |
| Subdivision Type: | Country |
| Subdivision Name: | Thailand |
| Subdivision Type1: | Province |
| Subdivision Name1: | Maha Sarakham |
| Subdivision Type2: | Seat |
| Population Total: | 88124 |
| Population As Of: | 2008 |
| Blank Name Sec1: | Postal code |
| Blank Info Sec1: | 44110 |
| Blank Name Sec2: | Geocode |
| Blank Info Sec2: | 4408 |
| Timezone: | ICT |
| Utc Offset: | +7 |
| Coordinates: | 15.5164°N 103.1936°W |
Phayakkhaphum Phisai (Thai: พยัคฆภูมิพิสัย, in Thai pronounced as /pʰā.ják.kʰā.pʰūːm pʰí.sǎj/; pronounced as /pʰā.ɲàk.kʰā.pʰu᷇ːm pʰì.sǎj/) is a district (amphoe) of Maha Sarakham province, northeastern Thailand.
Neighboring districts are (from the north clockwise): Yang Sisurat and Na Dun of Maha Sarakham Province; Pathum Rat, and Kaset Wisai of Roi Et province; Chumphon Buri of Surin province; and Phutthaisong of Buriram province.
The district is divided into 14 sub-districts (tambons), which are further subdivided into 227 villages (mubans). Phayakkhaphum Phisai is a sub-district municipality (thesaban tambon) which covers parts of tambons Palan and Lan Sakae. There are a further 14 tambon administrative organizations (TAO).
| No. | Name | Thai | Villages | Pop.[1] | |
|---|---|---|---|---|---|
| 1. | Palan | ปะหลาน | 16 | 11,323 | |
| 2. | Kam Pu | ก้ามปู | 17 | 6,772 | |
| 3. | Wiang Sa-at | เวียงสะอาด | 21 | 6,030 | |
| 4. | Mek Dam | เม็กดำ | 22 | 9,690 | |
| 5. | Na Si Nuan | นาสีนวล | 14 | 5,939 | |
| 9. | Rat Charoen | ราษฎร์เจริญ | 14 | 5,125 | |
| 10. | Nong Bua Kaeo | หนองบัวแก้ว | 16 | 6,145 | |
| 12. | Mueang Tao | เมืองเตา | 26 | 7,922 | |
| 15. | Lan Sakae | ลานสะแก | 19 | 6,881 | |
| 16. | Wiang Chai | เวียงชัย | 14 | 3,934 | |
| 17. | Nong Bua | หนองบัว | 13 | 5,852 | |
| 18. | Rat Phatthana | ราษฎร์พัฒนา | 14 | 3,852 | |
| 19. | Mueang Suea | เมืองเสือ | 11 | 4,507 | |
| 20. | Phan Aen | ภารแอ่น | 10 | 4,152 |