Pharmacogene Variation Consortium Explained

PharmVar
Description:	The PharmVar Consortium
Scope:	Pharmacogenomics and Pharmacogenetics
Organism:	Human
Center:	Children's Mercy Hospital
Pmid:	29134625
Released:	2017
Curation:	Yes

Pharmacogene Variation Consortium (abbreviated as PhamVar) is an international group of experts that maintains a systematic nomenclature system for allelic variations of genes that affect the metabolism of drugs.^{[1] [2]}

The database is focused on cytochrome P450 enzymes, but is being expanded into other classes of enzymes. The original nomenclature was maintained by the Human CYP Allele Nomenclature Database. However PhamVar took over this function in 2017.^[3]

See also

• PharmGKB
• pharmacogenetics
• pharmacogenomics
• pharmacokinetics
• pharmacodynamics
• Clinical Pharmacogenetics Implementation Consortium

Notes and References

1. Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE . The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database . Clinical Pharmacology and Therapeutics . 103 . 3 . 399–401 . March 2018 . 29134625 . 5836850 . 10.1002/cpt.910 .
2. Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Twist GP, Klein TE, Miller NA . The Evolution of PharmVar . Clinical Pharmacology and Therapeutics . 105 . 1 . 29–32 . January 2019 . 30536702 . 6312487 . 10.1002/cpt.1275 .
3. Book: Tornio A, Backman JT . Pharmacogenetics . Cytochrome P450 in Pharmacogenetics: An Update . Advances in Pharmacology . San Diego, Calif. . 83 . 3–32 . 2018 . 29801580 . 10.1016/bs.apha.2018.04.007 . 10138/300396 . 9780128133811 .