| Peyrusse-Grande | |
| Commune Status: | Commune |
| Arrondissement: | Auch |
| Canton: | Fezensac |
| Insee: | 32315 |
| Postal Code: | 32320 |
| Mayor: | William Villeneuve[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Artagnan en Fézensac |
| Coordinates: | 43.6333°N 0.215°W |
| Elevation M: | 245 |
| Elevation Min M: | 151 |
| Elevation Max M: | 269 |
| Area Km2: | 25.5 |
Peyrusse-Grande (in French pronounced as /peʁys ɡʁɑ̃d/; Occitan (post 1500);: Peirussa Grana) is a commune in the Gers department in southwestern France.
The Auzoue forms part of the commune's eastern border.
The Douze forms most of the commune's western border.