| Petrosino | |
| Official Name: | Comune di Petrosino |
| Coordinates: | 37.7167°N 41°W |
| Region: | Sicily |
| Province: | Trapani (TP) |
| Mayor: | Giacomo Anastasi (since June 12, 2022) |
| Area Total Km2: | 44 |
| Population Total: | 7458 |
| Population As Of: | December 31, 2004 |
| Population Demonym: | Petrosinesi |
| Elevation M: | 16 |
| Saint: | St. Mary of the Graces |
| Day: | May 31 |
| Postal Code: | 91020 |
| Area Code: | 0923 |
Petrosino (Sicilian: Pitrusinu) is a town and comune in Sicily, Italy, administratively part of the province of Trapani, located between the municipalities of Marsala and Mazara del Vallo.