Peter M. Howley Explained
Peter Maxwell Howley (born October 9, 1946)[1] is an American pathologist,[2] virologist, and professor at Harvard Medical School.[3] He has been president of the American Society for Virology and the American Society for Investigative Pathology and a co-editor of the .
Biography
Howley was born in New Brunswick, New Jersey. He graduated in 1968 from Princeton University with an A.B. in chemistry and in 1970 from Rutgers University with an M.M.S. (Master of Medical Science) degree. In 1972 he graduated with an M.D. from Harvard Medical School. From 1972 to 1973 he worked as an intern in pathology at Massachusetts General Hospital. He was a research associate from 1973 to 1975 at the National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, Maryland. In 1977 he was granted board certification in anatomic pathology. At the NCI's Laboratory of Pathology, Howley was from 1975 to 1976 a resident, from 1976 to 1977 a junior staff pathologist, from 1977 to 1979 a senior investigator, and from 1979 to 1984 Chief of the Viral Oncology and Molecular Pathology Section. From 1984 to 1993 he was Chief of the NCI's Laboratory of Tumor Virus Biology.In 1991, Howley became the George Fabyan Professor of Comparative Pathology at Harvard Medical School.[4] He was the president of the American Society for Virology from 1998 to 1999[5] and the president of the American Society for Investigative Pathology in 2006.[6] By 2009 he was the Shattuck Professor of Pathology.[7]
Howley is considered to be a leader in research on papillomaviruses. Howley and his co-workers created gene maps of many species of papillomaviruses and analyzed their transcription patterns and systems of transcription regulation. The research identified papillomavirus oncogenes and the molecular mechanisms of their damaging effects. This work is considered fundamental for the understanding of the pathogenesis of papillomaviruses at the molecular level.[8]
Peter M. Howley and David M. Knipe have been co-editors-in-chief, since the 3rd edition, of Fields Virology, a standard work on virology, with 5th edition published in 2006 and 6th edition published in 2013. Howley is also one of the chief editors of The Molecular Basis of Cancer, published by Elsevier.[9] [10] He was a co-editor of the from 2007 - 2015.[11] He is a member of the editorial board of the Proceedings of the National Academy of Sciences.[8]
He is married with three children.[1]
Peter M. Howley should not be confused with Paul M. Howley, who is a managing director of the vaccine biotechnology firm VAXMED Pty Ltd in Melbourne, Australia.[12]
Awards and honors
Selected publications
- 10.1038/287072a0. In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA. 1980. Lowy. Douglas R.. Dvoretzky. Israel. Shober. Ralph. Law. Ming-Fan. Engel. Linda. Howley. Peter M.. Nature. 287. 5777. 72–74. 6251381. 1980Natur.287...72L. 4278780. 1980
- 10.1073/pnas.78.5.2727. Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences. 1981. Law. M. F.. Lowy. D. R.. Dvoretzky. I.. Howley. P. M.. Proceedings of the National Academy of Sciences. 78. 5. 2727–2731. 6265905. 319430. 1981PNAS...78.2727L. free. 1981
- 10.1038/299529a0. The primary structure and genetic organization of the bovine papillomavirus type 1 genome. 1982. Chen. Ellson Y.. Howley. Peter M.. Levinson. Arthur D.. Seeburg. Peter H.. Nature. 299. 5883. 529–534. 6289124. 1982Natur.299..529C. 4330135. free. 1982
- 10.1073/pnas.82.4.1030. Bovine papillomavirus contains multiple transforming genes. 1985. Yang. Y. C.. Okayama. H.. Howley. P. M.. Proceedings of the National Academy of Sciences. 82. 4. 1030–1034. 2983327. 397187. 1985PNAS...82.1030Y. free. 1985
- 10.1073/pnas.83.24.9759. Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. 1986. Howard E. Gendelman. Gendelman. H. E.. Phelps. W.. Feigenbaum. L.. Ostrove. J. M.. Adachi. A.. Howley. P. M.. Khoury. G.. Ginsberg. H. S.. Martin. M. A.. Proceedings of the National Academy of Sciences. 83. 24. 9759–9763. 2432602. 387220. 1986PNAS...83.9759G. free. 1986
- 10.1126/science.2537532. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. 1989. Dyson. N.. Howley. P.. Munger. K.. Harlow. E.. Science. 243. 4893. 934–937. 2537532. 1989Sci...243..934D. 1989
- 10.1126/science.2157286. Association of human papillomavirus types 16 and 18 E6 proteins with p53. 1990. Werness. B.. Levine. A.. Howley. P.. Science. 248. 4951. 76–79. 2157286. 1990Sci...248...76W. 1990
- 10.1002/j.1460-2075.1991.tb04990.x. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. 1991. Huibregtse. J.M.. Scheffner. M.. Howley. P.M.. The EMBO Journal. 10. 13. 4129–4135. 1661671. 453163. 1991
- 10.1073/pnas.88.13.5523. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. 1991. Scheffner. M.. Munger. K.. Byrne. J. C.. Howley. P. M.. Proceedings of the National Academy of Sciences. 88. 13. 5523–5527. 1648218. 51909. 1991PNAS...88.5523S. free. 1991
- 10.1073/pnas.89.10.4549. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 1992. Chellappan. S.. Kraus. V. B.. Kroger. B.. Munger. K.. Howley. P. M.. Phelps. W. C.. Nevins. J. R.. Proceedings of the National Academy of Sciences. 89. 10. 4549–4553. 1316611. 49120. 1992PNAS...89.4549C. 23812634. free. 1992
- 10.1073/pnas.92.7.2563. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. 1995. Huibregtse. J. M.. Scheffner. M.. Beaudenon. S.. Howley. P. M.. Proceedings of the National Academy of Sciences. 92. 7. 2563–2567. 7708685. 42258. 1995PNAS...92.2563H. free. 1995
- 10.1073/pnas.94.9.4412. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton. 1997. Tong. X.. Howley. P. M.. Proceedings of the National Academy of Sciences. 94. 9. 4412–4417. 9114003. 20736. 1997PNAS...94.4412T. free. 1997
- Wathelet. Marc G. Lin. Charles H. Parekh. Bhavin S. Ronco. Lucienne V. Howley. Peter M. Maniatis. Tom. Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo. Molecular Cell. 1. 4. 1998. 507–518. 1097-2765. 10.1016/S1097-2765(00)80051-9. 9660935. free.
- 10.1126/science.286.5443.1321. Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade. 1999. Huang. L.. Kinnucan. E.. Wang. G.. Beaudenon. S.. Howley. P. M.. Huibregtse. J. M.. Pavletich. N. P.. Science. 286. 5443. 1321–1326. 10558980. 1999
- Münger. Karl. Howley. Peter M. Human papillomavirus immortalization and transformation functions. Virus Research. 89. 2. 2002. 213–228. 0168-1702. 10.1016/S0168-1702(02)00190-9. 12445661.
- 1500926. 2006. Howley. P. M.. Warts, Cancer and Ubiquitylation: Lessons from the Papillomaviruses. Transactions of the American Clinical and Climatological Association. 117. 113–127. 18528468.
- White. E. A.. Sowa. M. E.. Tan. M. J. A.. Jeudy. S.. Hayes. S. D.. Santha. S.. Münger. K.. Harper. J. W.. Howley. P. M.. Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proceedings of the National Academy of Sciences. 109. 5. 2012. E260–E267. 0027-8424. 10.1073/pnas.1116776109. 22232672. 3277141. free.
- Howley. Peter M.. Pfister. Herbert J.. Beta genus papillomaviruses and skin cancer. Virology. 479-480. 2015. 290–296. 0042-6822. 10.1016/j.virol.2015.02.004. 25724416. 4424140. free.
Notes and References
- Web site: Curricum Vitae: Peter M. Howley, M.D.. Tobacco Documents Online. https://web.archive.org/web/20140822004915/http://tobaccodocuments.org/ctr/CTRMN011011-1020.html. 2014-08-22.
- Web site: DF/HCC Dana-Farber/Harvard Cancer Center. Peter M. Howley, MD.
- Web site: BBS Faculty Member - Peter Howley. BBS PhD Program in Biological and Biomedical Sciences, Harvard Medical School (hms.harvard.edu).
- Book: Harvard University History of Named Chairs: Sketches of Donors and Donations 1991 – 2004 . 2005 . Harvard University . Cambridge, Massachusetts . 100–103 .
- Web site: Presidents of The American Society for Virology . American Society for Virology . 4 October 2021.
- Web site: Past Officers of ASIP (Formerly the American Association of Pathologists) . American Society for Investigative Pathology (ASIP) . 4 October 2021.
- Web site: The 2009 Harvard / Paul F. Glenn Symposium on Aging June 8, 2009 . Paul F. Glenn Laboratories at Harvard Medical School.
- Web site: Peter M Howley, MD. The Vallee Foundation.
- Book: Mendelsohn, John. Howley, Peter M.. Israel, Mark A.. Gray, Joe W.. Thompson, Craig B.. The Molecular Basis of Cancer: Expert Consult - Online. 1 April 2008. Elsevier Health Sciences. 978-1-4377-1099-1.
- Book: Mendelsohn, J.. Howley, P. M.. Israel, M. A.. Gray, J. W.. Thompson, C. B.. 2014. The Molecular Basis of Cancer E-Book. Elsevier Health Sciences. 978-0-323-26196-8.
- 10.1086/523214. Annual Review of Pathology: Mechanisms of Disease. Volume 2: 2007. Edited by Abul K Abbas,, Stephen J Galli, and, Peter M Howley. Palo Alto (California): Annual Reviews. $55.00. Xii + 429 p; ill.; no index. 978-0-8243-4302-6. 2007.. The Quarterly Review of Biology. 2007. 82. 3. 311.
- Prow. Natalie A.. Liu. Liang. McCarthy. Mary K.. Walters. Kevin. Kalkeri. Raj. Geiger. Jillian. Koide. Fusataka. Cooper. Tamara H.. Eldi. Preethi. Nakayama. Eri. Diener. Kerrilyn R.. Howley. Paul M.. Hayball. John D.. Morrison. Thomas E.. Suhrbier. Andreas. The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates. npj Vaccines. 5. 1. 2020. 44. 2059-0105. 10.1038/s41541-020-0191-8. 32550013. 7265471. free.
- 1916352. 1983. Howley. P. M.. The molecular biology of papillomavirus transformation. Warner-Lambert Parke-Davis Award Lecture. The American Journal of Pathology. 113. 3. 414–421. 6316792.
- 1853043. 1998. Cotran. R. S.. Forty Years of the Warner-Lambert/ Parke-Davis Award : A Remarkable Record. The American Journal of Pathology. 153. 4. 1014. 10.1016/S0002-9440(10)65644-1. 9777931.
- Web site: Wallace P. Rowe Award Plaque. Office of History, National Institutes of Health.
- Web site: Peter M. Howley, MD . American Society for Clinical Investigation.
- Web site: Peter M. Howley. National Academy of Sciences (nasonline.org).
- Web site: Goethe-Universität — Preisträger seit 1952 (prizewinners since 1952). Uni-frankfurt.de. de.
- Web site: Book of Members 1780—present, Chapter H. American Academy of Arts and Sciences.
- Web site: ASIP Rous-Whipple Award . American Society for Investigative Pathology . en.
- Web site: Event Release - May 2011, News Publications. Robert Wood Johnson Medical School, Rutgers University.
- Web site: 2015 Recipients of NCI Outstanding Investigator Awards - NCI . National Cancer Institute . 14 June 2023 . en . 14 October 2015.