Peter Colman Explained

Peter Colman
Birth Name:Peter Malcolm Colman
Birth Date:1944 4, df=yes
Birth Place:Adelaide
Thesis Title:The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts
Thesis Url:http://hdl.handle.net/2440/19998
Thesis Year:1969
Doctoral Advisor:Harry Medlin

Peter Malcolm Colman (born 1944) is the head of the structural biology division at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia.

Education

Colman was educated at the University of Adelaide, where he received a Bachelor of Science degree in physics in 1966 and a PhD in 1969 for research on the chemical structure of parabanic acid complexes supervised by Harry Medlin.[1]

Research and career

Colman's research interests are in structural biology,[2] [3] especially of human B-cell lymphoma 2 (BCL-2).[4] [5] [6] [7] Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir, the first-in-class neuraminidase inhibitor for influenza. His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets. His discoveries underpin drug stockpiling for pandemic preparedness. He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes. Recent work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane, an essential step in the intrinsic cell-death pathway.[8]

His work has been published in leading peer reviewed scientific journals including Nature,[2] [9] [10] [11] [12] [13] the Journal of Molecular Biology,[14] and Nature Reviews Molecular Cell Biology.[15]

Awards and honours

In the Queen's 2017 Birthday Honours Colman was appointed a Companion of the Order of Australia (AC), Australia's highest civilian honour, "for eminent service to medical research, particularly in the fields of structural biology and medicinal chemistry, as a leader in the commercial translation of scientific discoveries, to professional organisations, and as a mentor of young scientists".[16]

Colman was elected a Fellow of the Royal Society (FRS) in 2014.[8] In 2001 he was awarded a Centenary Medal "For service to Australian society and science in structural biology".[17] Colman was also elected a Fellow of the Australian Academy of Science in 1989 and a Fellow of the Australian Academy of Technological Sciences and Engineering in 1997. He was awarded the Lemberg Medal in 1988[18] and the Macfarlane Burnet Medal and Lecture in 1995.[19]

Notes and References

  1. PhD . Peter Malcolm. Colman . The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts . 1969 . Peter Colman. University of Adelaide. 222734513. trove.nla.gov.au. 2440/19998.
  2. 10.1038/264415a0. 1004567. Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature. 264. 5585. 415–20. 1976. Huber . R. . Robert Huber. Deisenhofer . J. . Johann Deisenhofer. Colman . P. M. . Peter Colman. Matsushima . M. . Palm . W. . 1976Natur.264..415H . 4193312.
  3. 10.1016/S0923-2494(94)80039-1. 7516563. Effects of amino acid sequence changes on antibody-antigen interactions. Research in Immunology. 145. 1. 33–6. 1994. Colman . P. M. .
  4. 10.1038/nrd2658. 19043450. BCL-2 family antagonists for cancer therapy. Nature Reviews Drug Discovery. 7. 12. 989–1000. 2008. Lessene . G. . Czabotar . P. E. . Colman . P. M. . 7385925.
  5. 10.1021/jm401948b. 24456288. De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization. Journal of Medicinal Chemistry. 57. 4. 1323–43. 2014. Brady . R. M. . Vom . A. . Roy . M. J. . Toovey . N. . Smith . B. J. . Moss . R. M. . Hatzis . E. . Huang . D. C. S. . Parisot . J. P. . Yang . H. . Street . I. P. . Colman . P. M. . Czabotar . P. E. . Baell . J. B. . Lessene . G. .
  6. 10.1021/ml500030p. 24944740. Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Medicinal Chemistry Letters. 5. 6. 662–7. 2014. Koehler . M. F. T. . Bergeron . P. . Choo . E. F. . Lau . K. . Ndubaku . C. . Dudley . D. . Gibbons . P. . Sleebs . B. E. . Rye . C. S. . Nikolakopoulos . G. . Bui . C. . Kulasegaram . S. . Kersten . W. J. A. . Smith . B. J. . Czabotar . P. E. . Colman . P. M. . Huang . D. C. S. . Baell . J. B. . Watson . K. G. . Hasvold . L. . Tao . Z. F. . Wang . L. . Souers . A. J. . Elmore . S. W. . Flygare . J. A. . Fairbrother . W. J. . Lessene . G. . 4060937.
  7. 10.1016/j.molcel.2004.12.030. 15694340. Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function. Molecular Cell. 17. 3. 393–403. 2005. Chen . L. . Willis . S. N. . Wei . A. . Smith . B. J. . Fletcher . J. I. . Hinds . M. G. . Colman . P. M. . Day . C. L. . Adams . J. M. . Huang . D. C. S. . free .
  8. Web site: https://web.archive.org/web/20150505083411/https://royalsociety.org/people/fellowship/2014/peter-colman/ . 2015-05-05 . Professor Peter Colman FRS . Royal Society. royalsociety.org. Anon. 2014 . London. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  9. 10.1038/363418a0. 8502295. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature. 363. 6428. 418–23. 1993. von Itzstein . M. . Wu . W. Y. . Kok . G. B. . Pegg . M. S. . Dyason . J. C. . Jin . B. . Phan . T. V. . Smythe . M. L. . White . H. F. . Oliver . S. W. . Colman . P. M. . Varghese . J. N. . Ryan . D. M. . Woods . J. M. . Bethell . R. C. . Hotham . V. J. . Cameron . J. M. . Penn . C. R. . 1993Natur.363..418V . 4359333.
  10. Chothia . C. . Cyrus Chothia. Lesk . A. M. . Arthur M. Lesk. Tramontano . A. . Levitt . M. . Michael Levitt (biophysicist). Smith-Gill . S. J. . Air . G. . Sheriff . S. . Padlan . E. A. . Davies . D. . Tulip . 10.1038/342877a0 . W. R. . Colman . P. M. . Peter Colman. Spinelli . S. . Alzari . P. M. . Poljak . R. J. . Conformations of immunoglobulin hypervariable regions . Nature . 342 . 6252 . 877–883 . 1989 . 2687698 . 1989Natur.342..877C . 4241051 .
  11. 10.1038/303035a0. 6843658. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution. Nature. 303. 5912. 35–40. 1983. Varghese . J. N.. Laver . W. G.. Colman . P. M.. 1983Natur.303...35V. 4363648.
  12. 10.1038/326358a0. 2436051. Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature. 326. 6111. 358–63. 1987. Colman . P. M.. Laver . W. G.. Varghese . J. N.. Baker . A. T.. Tulloch . P. A.. Air . G. M.. Webster . R. G.. 1987Natur.326..358C. 4239913.
  13. 10.1038/303041a0. 6188957. Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature. 303. 5912. 41–4. 1983. Colman . P. M.. Varghese . J. N.. Laver . W. G.. 1983Natur.303...41C. 4325977.
  14. 10.1006/jmbi.1993.1648. 8263940. Shape Complementarity at Protein/Protein Interfaces. Journal of Molecular Biology. 234. 4. 946–50. 1993. Lawrence . M. C. . Colman . P. M. .
  15. 10.1038/nrm1076. 12671653. The structural biology of type I viral membrane fusion. Nature Reviews Molecular Cell Biology. 4. 4. 309–19. 2003. Colman . P. M. . Lawrence . M. C. . 31703688.
  16. http://www.gg.gov.au/sites/default/files/files/honours/qb/qb2017/mnxi3_8skq/Media%20Notes%20-%20AC.pdf Companion (AC) in the General Division of the Order of Australia
  17. https://www.itsanhonour.gov.au/honours/honour_roll/search.cfm?breif=false&page=1&search_view=~all~&view=10&search_type=simple COLMAN, Peter Malcolm - Centenary Medal
  18. Web site: Lemberg Medal Winners . 2024-01-31 . Australian Society for Biochemistry and Molecular Biology.
  19. Web site: Macfarlane Burnet Medal and Lecture. Australian Academy of Science. 2017-02-22.

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