| Persimmon Gap | |
| Other Name: | South Pass |
| Map: | Texas |
| Map Relief: | 1 |
| Label: | Persimmon Gap |
| Elevation M: | 902 |
| Elevation Ft: | 2959 |
| Location: | Brewster County, Texas, United States |
| Range: | Santiago Mountains |
| Coordinates: | 29.6682°N -103.1707°W |
Persimmon Gap is a mountain pass located in Big Bend National Park in Texas.
It is traversed by U.S. Highway 385.
The hottest temperature recorded in Persimmon Gap was 113F on June 18, 2017, while the coldest temperature recorded was 4F on December 23, 1989.