Pernette Du Guillet (c.1520 – July 7, 1545) was a female French poet of the Renaissance.
She was born into a noble family in Lyon, and married in 1537 or 1538 a man with the last name Du Guillet. In the spring of 1536, she met the poet Maurice Scève (she was 16; he was 35), and she would serve as Scève's poetic muse, inspiring his Délie. From this work has come the reputation of her beauty and significant culture. She lived in Lyon,[1] which was culturally blooming during her lifetime. After her death, her poetry was published in Rymes de Gentille et Vertueuse Dame, Pernette du Guillet.