Perlia's nucleus explained

Perlia's nucleus, also known as nucleus of Perlia and abbreviated as NP, is a nucleus located in the mesencephalon, in front of the Edinger-Westphal nucleus^[1] and between the right and left oculomotor nuclei, it is implicated in parasympathetic oculomotor functions, possibly including input to the iris and ciliary.^[2] Perlia's nucleus is believed to be a characteristic found exclusively in animals capable of binocular vision. Moreover, it might be an exclusive characteristic of humans, as indicated by a systematic study of monkey brains, where only 9% exhibited a clear midline group, potentially corresponding to the NP.^[3]

In 1891, Perlia's nucleus was identified as a central mediator for the convergent movement of the eyes based on clinical findings in ophthalmospegias.^[4] It has also recently been attributed an important role in the upward movement or gaze of the eyes.

See also

• Edinger–Westphal nucleus

Notes and References

1. Ogut . Eren . Kaya . Pamirhan . Karakas . Ozge . Yildiz . Edanur . Sozge . Ilgin . 2024-04-07 . Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia . Acta Neurologica Belgica . en . 10.1007/s13760-024-02533-w . 2240-2993.
2. Web site: NEUROANATOMY I. - Structures of the CNS . 2023-09-08 . www.nan.upol.cz.
3. Kozicz . Tamás . Bittencourt . Jackson C. . May . Paul J. . Reiner . Anton . Gamlin . Paul D. R. . Palkovits . Miklós . Horn . Anja K.E. . Toledo . Claudio A. B. . Ryabinin . Andrey E. . The Edinger-Westphal nucleus: A historical, structural, and functional perspective on a dichotomous terminology . 2011-06-01 . The Journal of Comparative Neurology . 519 . 8 . 1413–1434 . 10.1002/cne.22580 . 0021-9967 . 3675228 . 21452224.
4. Warwick . Roger . 1955 . THE SO-CALLED NUCLEUS OF CONVERGENCE . Brain . en . 78 . 1 . 92–114 . 10.1093/brain/78.1.92 . 0006-8950.