Peripheral odontogenic fibroma explained

Peripheral odontogenic fibroma
Synonyms:	PFO

Peripheral odontogenic fibroma (PFO) is a fibrous connective tissue mass that is exophytic and covered in surface epithelium that contains odontogenic epithelium.^[1] The World Health Organization (WHO) classifies peripheral odontogenic fibroma as a fibroblastic neoplasm with variable amounts of odontogenic epithelium that appears to be dormant. Dentine and/or cementum-like material may be present.^[2]

Signs and symptoms

Peripheral odontogenic fibroma manifests clinically as an infrequent, benign, unencapsulated exophytic mass that can be sessile or pedunculated, red or pink, smooth-surfaced, and ulcerated in some cases. It is frequently found on the attached gingiva, mainly in the molar and premolar regions, though it can be found anywhere in the jaw.^[3]

Diagnosis

Clinically, there is no way to differentiate peripheral odontogenic fibroma from other common fibrous gingival lesions,^[4] including peripheral giant cell lesion, pyogenic granuloma, inflammatory fibrous hyperplasia, and peripheral ossifying fibroma.^[5] Rarely have diffuse or multifocal lesions been reported. ^[4] Lesions that are larger may show signs of mineralization, although radiographic changes are uncommon, particularly in the early stages.^[5] Histopathologic features include a proliferation of relatively cellular fibrous or fibromyxomatous connective tissue with variable amounts of odontogenic epithelium and occasionally foci of calcification in the form of dentinoid, cementicles, or bone. These features are similar to those of the central odontogenic fibroma.^[6]

Treatment

The preferred course of treatment is conservative local excision.^[7]

Outlook

The rate of recurrence varies wildly. According to some studies, peripheral odontogenic fibroma has a low recurrence rate.^[8] One study showed a recurrence rate of 38.9%,^[9] while another study showed a recurrence rate of 50%.^[10]

Epidemiology

The literature has reported a slight female predominance in this neoplasm, which occurs in a wide age range from the first to the ninth decades of life with a peak in the second and fourth decades.^[11]

See also

• Peripheral ossifying fibroma
• Central odontogenic fibroma

Further reading

• Khot . Komal . Deshmane . Swati . Bagri-Manjrekar . Kriti . Khot . Paresh . Peripheral Odontogenic Fibroma: A Rare Tumor mimicking a Gingival Reactive Lesion . International Journal of Clinical Pediatric Dentistry . Jaypee Brothers Medical Publishing . 10 . 1 . 2017 . 0974-7052 . 10.5005/jp-journals-10005-1416 . 103–106 . 28377665 . 5360813 . none.
• Silva . Carolina Amália Barcellos . Passador-Santos . Fabrício . Moraes . Paulo de Camargo . Soares . Andresa Borges . de Araújo . Vera Cavalcanti . Peripheral Odontogenic Fibroma . Journal of Craniofacial Surgery . Ovid Technologies (Wolters Kluwer Health) . 24 . 3 . 2013 . 1049-2275 . 10.1097/scs.0b013e3182802532 . e216–e219 . none.

External links

• DermNet
• Odontogenic fibroma at Pathology Outlines.

Notes and References

1. MARTELLI‐JÚNIOR . H. . MESQUITA . R. A. . DE PAULA . A. M. B. . PÊGO . S. P. B. . SOUZA . L. N. . Peripheral odontogenic fibroma (WHO type) of the newborn: a case report . International Journal of Paediatric Dentistry . Wiley . 16 . 5 . 2006 . 0960-7439 . 10.1111/j.1365-263x.2006.00738.x . 376–379. 16879337 .
2. Book: Kramer . I. R. H. . Pindborg . J. J. . Shear . M. . Histological Typing of Odontogenic Tumours . Histological Classification of Odontogenic Tumours . Springer Berlin Heidelberg . Berlin, Heidelberg . 1992 . 978-3-540-54142-4 . 10.1007/978-3-662-02858-2_2 . 7–9.
3. Nikam . ShitalSudhakar . Gadgil . RajeevM . Bhoosreddy . AjayR . Shah . KaranR . Peripheral odontogenic fibroma: A case report and review of literature . Journal of Indian Academy of Oral Medicine and Radiology . Medknow . 27 . 1 . 2015 . 0972-1363 . 10.4103/0972-1363.167138 . 140 . free.
4. Baiju . CS . Rohatgi . Sumidha . Peripheral odontogenic fibroma: A case report and review . Journal of Indian Society of Periodontology . Medknow . 15 . 3 . 2011 . 0972-124X . 10.4103/0972-124x.85674 . 273 . free . 3200026 .
5. Patel . Stavan . Vakkas . John . Mandel . Louis . Recurrent peripheral odontogenic fibroma. Case report . The New York State Dental Journal . 2011 . 77 . 4 . 35–37 . 21894830.
6. Gardner . David G. . The peripheral odontogenic fibroma: An attempt at clarification . Oral Surgery, Oral Medicine, Oral Pathology . Elsevier BV . 54 . 1 . 1982 . 0030-4220 . 10.1016/0030-4220(82)90415-7 . 40–48.
7. Eversole . Lewis R. . Odontogenic Fibroma, Including Amyloid and Ossifying Variants . Head and Neck Pathology . Springer Science and Business Media LLC . 5 . 4 . July 13, 2011 . 1936-055X . 10.1007/s12105-011-0279-6 . 335–343. 21751042 . 3210224 .
8. Slabbert . Hein de Villiers . Altini . Mario . Peripheral odontogenic fibroma: A clinicopathologic study . Oral Surgery, Oral Medicine, Oral Pathology . Elsevier BV . 72 . 1 . 1991 . 0030-4220 . 10.1016/0030-4220(91)90195-i . 86–90.
9. Daley . Tom D. . Wysocki . George P. . Peripheral odontogenic fibroma . Oral Surgery, Oral Medicine, Oral Pathology . Elsevier BV . 78 . 3 . 1994 . 0030-4220 . 10.1016/0030-4220(94)90064-7 . 329–336. 7970594 .
10. Ritwik . Priyanshi . Brannon . Robert B. . Peripheral odontogenic fibroma: a clinicopathologic study of 151 cases and review of the literature with special emphasis on recurrence . Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology . Elsevier BV . 110 . 3 . 2010 . 1079-2104 . 10.1016/j.tripleo.2010.04.018 . 357–363. 20674403 .
11. Garcia . BG . Johann . ACBR . da Silveira-Júnior . JB . Aguiar . MC . Mesquita . RA . Retrospective analysis of peripheral odontogenic fibroma (WHO-type) in Brazilians . Minerva Stomatologica . March 2007 . 56 . 3 . 115–119 . 17327815 . 19 December 2023.