Perfluorooctanesulfonic acid explained

Perfluorooctanesulfonic acid (PFOS) (conjugate base perfluorooctanesulfonate) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group, and thus it is a perfluorosulfonic acid and a perfluoroalkyl substance (PFAS). It is an anthropogenic (man-made) fluorosurfactant, now regarded as a global pollutant. PFOS was the key ingredient in Scotchgard, a fabric protector made by 3M, and related stain repellents. The acronym "PFOS" refers to the parent sulfonic acid and to various salts of perfluorooctanesulfonate. These are all colorless or white, water-soluble solids. Although of low acute toxicity, PFOS has attracted much attention for its pervasiveness and environmental impact. It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009.[1]

History

In 1949, 3M began producing PFOS-based compounds by electrochemical fluorination.[2] In 1968, organofluorine compounds were detected in the blood serum of consumers, and in 1976, perfluorooctanoic acid (PFOA) or a related compound such as PFOS were suggested as components.[3] [4] [5] In 1997, 3M detected PFOS in blood from global blood banks,[6] although the company's internal documents indicate knowledge of this decades earlier, dating from the 1970s.[7] In 1999, the U.S. Environmental Protection Agency began investigating perfluorinated compounds after receiving data on the global distribution and toxicity of PFOS, the key ingredient in Scotchgard.[8] For these reasons, and USEPA pressure,[9] the primary American producer of PFOS, 3M, announced, in May 2000, the phaseout of the production of PFOS, PFOA, and PFOS-related products.[10] Most other manufacturers (particularly, those in Europe) phased out the production of PFOS and perfluorooctanoic acid (PFOA) in 2000 and 2006, respectively. A shorter-chain PFOS (perfluorohexanesulfonic acid, PFHxS), was included in Annex A to the Stockholm Convention in 2022.[11]

Currently, most of PFOS and PFOS-related chemicals are produced in China.[12]

Chemistry

The main method used for the industrial scale production of PFOS is electrochemical fluorination (ECF).[13] ECF is an electrolysis method whereby the precursor of octanesulfonyl fluoride is electrolyzed in a solution of hydrogen fluoride to give perfluorooctanesulfonyl fluoride. This production method also results in shorter chain perfluoroalkyl substances being formed. PFOS predominates in the resultant mixture. A distinct isomer ratio has been observed in PFOS produced by ECF, in the order of 70% linear PFOS, 25% branched and 5% terminal; this is not a function of the production process but rather that the precursor also exhibits this isomer ratio. ECF was the means by which 3M produced PFOS up until May 2000 when the company announced a phaseout of fluorosurfactants.

Although 89 constitutional isomers of PFOS are possible,[14] environmental samples usually consist of a mixture of the linear isomer and 10 branched isomers.[15]

Telomerisation involves constructing the PFOS molecule using short chain (often 2-carbon) precursors and adding a sulfonate group as a final step. This production process results in 100% linear PFOS. This production method, whilst cleaner and resulting in a much purer product than ECF, is not known to have been widely used except for the production of reagent grade PFOS and analytical standards.

Indirect routes

Perfluorooctylsulfonyl compounds degrade to PFOS.[16] Examples include (N-MeFOSE), a carpet stain repellent, and (N-EtFOSE), a paper treatment.[17] Also perfluorooctanesulfonamide is a precursor.[18] About 50 precursors were named in the 2004 proposed Canadian ban on PFOS.[19]

Degradation

PFOS virtually does not degrade under environmental conditions and is thus highly persistent. Waste water treatment plants are also unable to degrade PFOS.[20] On the other hand, precursors are transformed to PFOS in waste water treatment plants.[21]

Properties

The C8F17 subunit of PFOS is hydrophobic and lipophobic, like other fluorocarbons, while the sulfonic acid/sulfonate group adds polarity. PFOS is an exceptionally stable compound in industrial applications and in the environment because of the effect of aggregate carbon–fluorine bonds. PFOS is a fluorosurfactant that lowers the surface tension of water more than that of hydrocarbon surfactants.

Uses

Perfluorooctanesulfonic acid is usually used as the sodium or potassium salts.

The most important emission sources of PFOS are metal plating and fire-fighting foams.[22] Because of concerns about PFOS, F-53B has been used as a replacement for mist suppression in metal plating.[23]

Levels in humans

Because of its chemical nature, PFOS will remain in the body for several years. It is estimated that it takes 4 years for half of this substance to be eliminated from the body.[24]

PFOS is detected in the blood serum of almost all people in the U.S., but concentrations have been decreasing over time. In contrast, PFOS blood levels appear to be rising in China[25] where PFOS production continues. A study of ca. 2000 teenagers from 9 European countries with most samples collected in years 2016-2018 found higher blood concentrations of several PFOS’s in those, who consumed more seafood, eggs or offal, as well as in those from North and West (versus the South and East) Europe. Within the same country, boys had a higher PFOS concentrations than girls. A typical PFOS blood concentration range in this study was 1,500-2,500 ppb.[26]

Much higher levels of blood PFOS (12,830 ppb) have been reported in people with occupational exposure [27] - or possibly 1,656 parts per billion[28] - in a consumer. Occupationally exposed individuals may have an average level of PFOS over 1000 parts per billion, and a small segment of individuals in the upper range of the general population may be over the 91.5 parts per billion level.[29]

PFOS exposure has been demonstrated as early as fetal development during pregnancy since PFOS can easily pass through the placenta.[30] It has been shown that fetal exposure to PFOS is quite prevalent and has been shown to be detected in greater than 99% of umbilical cord serum samples.[31]

PFOS has been detected in U.S. freshwater fish,[32] [33] as well as in municipal wastewater[34] and drinking water samples,[35] worldwide, at concentrations ranging between few ng/L and some μg/L.

Levels in wildlife

A variety of wildlife species have had PFOS levels measured in egg, liver, kidney, serum, and plasma samples and some of the highest recorded values as of January 2006 are listed below.[36]

SpeciesGeographyYearSamplePFOS (ppb)
Midwestern United States 1990–93 plasma 2,200
California, US 1997 liver 970
Baltic Sea, Sweden 1997 egg 614
Tokyo Bay, Japan 2000 liver 464
North Carolina, US 1998 liver 861
Sanikiluaq, Nunavut, Canada 2002 liver 3,100
Wadden Sea, the Netherlands 2002 muscle 2,725
Charleston, South Carolina, US 2003 plasma 1,315
Mediterranean Sea, Italy 1998 liver 940
Michigan, US 2000–01 liver 59,500
Ontario, Canada 2001 liver 72,900
near 3M, Port of Antwerp, Belgium 2007 liver 553–11,359[37]
Despite the global wide-ranging restriction, PFOS concentrations in air continued to increase at many monitoring stations between 2009 and 2017.[38]

Health effects in humans and wildlife

There is a growing body of research investigating the health effects of PFOS in humans and animals, including the reproductive, developmental, liver, kidney, thyroid, and immunological effects.[39] According to a 2002 report by the Environmental Directorate of the OECD, "PFOS is persistent, bioaccumulative, and toxic to mammalian species."[40]

Pregnancy outcomes

Several studies have focused on pregnancy outcomes in infants and mothers who are exposed to PFOS during pregnancy. For developing offspring, exposure to PFOS occurs through the placenta.[30] While the impact of PFOS compounds on fetal development continues to be an ongoing investigation, findings have demonstrated a relationship between PFOS exposure in pregnant mothers and negative birth outcomes.[41]

There has been some evidence to suggest that PFOS levels in pregnant women have been associated with preeclampsia, preterm labor, low birth weight and gestational diabetes.[42] [43] Although, the strongest association is between PFOS levels with preterm birth and preeclampsia.[44] There has been some evidence to suggest that PFOS impairs fetal growth during pregnancy, although findings have been inconsistent.

The specific physiological mechanisms behind adverse pregnancy outcomes with PFOS exposure remain unclear. One proposed cause has to do with PFOS impairment on placental blood flow.[39] This mechanism could help explain several of the pregnancy-related outcomes from PFOS exposure including such as intrauterine growth development, low birth weight, preterm birth labor, and preeclampsia. Additional physiological mechanisms may include disruption in inflammatory signals during pregnancy, decreased trophoblast signaling and trophoblast migration.[45] Additionally, PFOS exposure has been shown to be related to the downregulation genes corresponding to growth factors, pregnancy-related signal transducers, and maternal hormones.[46] PFOS impact on thyroid hormone regulation also has the potential to impact several birth outcomes.[47] [48]

Breastfeeding and lactation

PFOS has been measured in breastmilk and is estimated to contribute the greatest level of PFOS exposure in infants. Specifically, the duration of breastfeeding has been shown to be associated with increases in PFOS in infants.[49] Some evidence has shown that breastmilk provides more than 94% of the PFOS exposure in infants up to six months old.[50] The Agency for Toxic Substances and Disease Registry (ATSDR) concluded that breastfeeding benefits continue to outweigh potential risks associated with PFOS in breastmilk.[51]

Thyroid disease

Increased levels of PFOS have been shown to accumulate in thyroid gland cells and have been associated with altered thyroid hormone levels in adults.[52] [53] Appropriate levels of thyroid hormone during pregnancy are critical for a developing fetus as this hormone is involved with brain development and body growth. Studies have demonstrated a relationship between PFOS exposure and thyroid dysfunction during pregnancy resulting in altered thyroid hormone levels in both the mother and the fetus.[54] [55]

Hypercholesterolemia

PFOS has been associated with increased risk of abnormal levels of cholesterol.[56] [57] [58] Specifically, epidemiological studies in humans have reported an association between increased PFOS levels and the total cholesterol and low density lipoprotein (LDL) cholesterol.[59]

Chronic kidney disease

Serum levels of PFOS were found to be associated with increased risk of chronic kidney disease in the general US population.[60] "This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level."

Cancer

Research demonstrating the association between PFOS and cancer is still ongoing. A few studies have demonstrated an elevated risk for prostate and bladder cancer, however, there were notable limitations in the design and analysis of these studies. As of November 2023, the International Agency for Research on Cancer (IARC) has classified PFOS as possibly carcinogenic to humans (Group 2b) based on “strong” mechanistic evidence.[61] The Division of Cancer Epidemiology & Genetics (DCEG) is currently investigating the association of several PFAS compounds and cancers including kidney cancer, testicular cancer, prostate cancer, ovarian and endometrial cancer, thyroid cancer, non-hodgkins lymphoma, and childhood leukemia.[62]

In wildlife

The levels observed in wild animals are considered sufficient to "alter health parameters".[63] [64]

PFOS affects the immune system of male mice at a blood serum concentration of 91.5 parts per billion, raising the possibility that highly exposed people and wildlife are immunocompromised. Chicken eggs dosed at 1 milligram per kilogram (or 1 part per million) of egg weight developed into juvenile chickens with an average of ~150 parts per billion in blood serum - and showed brain asymmetry and decreased immunoglobulin levels.[65]

Regulation

Globally

It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009.[1] Originally, parties agreed on acceptable proposes (time-unlimited exemptions) for the following uses—in addition to a range of specific exemptions (time-limited):[66]

In 2019, it was decided to only keep one acceptable purpose:[67]

Canada

In 2023, the Government of Canada is considering addressing PFAS as a class rather than as individual substances or in smaller groups. A report to conclude that PFAS as a class are harmful to human health and the environment, and to define risk management aspects and alternatives to PFAs, is under development."Per-and polyfluoroalkyl substances (PFAS)"

Europe

Based on an OECD study on PFOS and a risk assessment by Europe's Scientific Committee on Health and Environmental Risks[68] the European Union practically banned the use of PFOS in finished and semi-finished products in 2006 (maximum content of PFOS: 0.005% by weight).[69] However, PFOS use for industrial applications (e.g. photolithography, mist suppressants for hard chromium plating, hydraulic fluids for aviation) was exempted.In 2009 this directive was incorporated into the REACH regulation.[70] In the summer of 2010 PFOS was added to the regulation on persistent organic pollutants and the threshold was lowered to max. 0.001% by weight (10 mg/kg).[71]

United States

In 2018 the State of Michigan established a legally enforceable groundwater cleanup level of 70 ppt for both PFOA and PFOS.[72]

In 2020 the Michigan Department of Environment, Great Lakes, and Energy (EGLE) adopted stricter drinking water standards in the form of maximum contaminant levels (MCLs), lowering acceptable levels from the 2018 enforceable groundwater cleanup levels of 70 ppt to 8 ppt for PFOA and 16 ppt for PFOS and adding MCLs for 5 previously unregulated PFAS compounds PFNA, PFHxA, PFHxS, PFBS, and HFPO-DA.[73] [74]

In 2020, a California bill was passed banning PFOS and the following salts as an intentionally added ingredient from cosmetics: ammonium perfluorooctane sulfonate, diethanolamine perfluorooctane sulfonate, lithium perfluorooctane sulfonate and potassium perfluorooctane sulfonate.[75]

In March 2021 the U.S. EPA announced that it will develop national drinking water standards for PFOA and PFOS.[76]

In October 2021 the EPA proposed to designate PFOA and PFOS as hazardous substances in its PFAS Strategic Roadmap.[77] [78] In September 2022 the EPA proposed to designate as hazardous substances under the Superfund Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA).

See also

External links

Notes and References

  1. Book: Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty . Stockholm Convention Secretariat . Geneva . 8 May 2009.
  2. A first global production, emission, and environmental inventory for perfluorooctane sulfonate . Environ. Sci. Technol. . 43 . 2 . 386–92 . January 2009 . 19238969 . 10.1021/es802216n. Paul AG, Jones KC, Sweetman AJ . 2009EnST...43..386P .
  3. Kennedy GL, Butenhoff JL, Olsen GW, etal . 8873920 . The toxicology of perfluorooctanoate . Crit. Rev. Toxicol. . 34 . 4 . 351–84 . 2004 . 15328768 . 10.1080/10408440490464705.
  4. Giesy JP, Kannan K . Perfluorochemical surfactants in the environment. Environ. Sci. Technol. . 36 . 7 . 146A–152A . April 2002. 11999053 . 10.1021/es022253t . free . 2002EnST...36..146G .
  5. Lau C, Butenhoff JL, Rogers JM . The developmental toxicity of perfluoroalkyl acids and their derivatives. Toxicol. Appl. Pharmacol.. 198 . 2 . 231–41 . July 2004. 15236955 . 10.1016/j.taap.2003.11.031 . 2004ToxAP.198..231L.
  6. Web site: The Inside Story: 3M and Scotchgard . Environmental Working Group . 29 May 2009 . https://web.archive.org/web/20090425144324/http://www.chemicalindustryarchives.org/dirtysecrets/scotchgard/1.asp . 25 April 2009 . dead . dmy-all.
  7. News: Fellner . Carrie . Toxic Secrets: Professor 'bragged about burying bad science' on 3M chemicals . 25 June 2018 . . 16 June 2018.
  8. Web site: Aziz . Ullah . The Fluorochemical Dilemma: What the PFOS/PFOA fuss is all about . Cleaning & Restoration . October 2006 . https://web.archive.org/web/20090305133928/https://www.restorationindustry.org/buyersguide/FlurochemicalsOct06.pdf . March 5, 2009 .
  9. News: Jennifer 8. . Lee . Jennifer 8. Lee. E.P.A. Orders Companies to Examine Effects of Chemicals . The New York Times . 15 April 2003 . 15 May 2009 .
  10. 3M: "PFOS-PFOA Information: What is 3M Doing?" Accessed October 25, 2008.
  11. Richterová . D. . Govarts . E. . Fábelová . L. . Rausová . K. . Rodriguez Martin . L. . Gilles . L. . Remy . S. . Colles . A. . Rambaud . L. . Riou . M. . Gabriel . C. . Sarigiannis . D. . Pedraza-Diaz . S. . Ramos . J.J. . Kosjek . T. . 2023 . PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021) . International Journal of Hygiene and Environmental Health . en . 247 . 114057 . 10.1016/j.ijheh.2022.114057 . 9758614 . 36327670. 2023IJHEH.24714057R .
  12. 10.1016/j.chemosphere.2014.09.021. A review of sources, multimedia distribution and health risks of perfluoroalkyl acids (PFAAs) in China. 2015. Wang. Tieyu. Wang. Pei. Meng. Jing. Liu. Shijie. Lu. Yonglong. Khim. Jong Seong. Giesy. John P.. Chemosphere. 129. 87–99. 25262946. 2015Chmsp.129...87W.
  13. Book: Risk profile on perfluorooctane sulfonate. POPs Review Committee. 2006.
  14. Rayne . Sierra . Forest . Kaya . Friesen . Ken J. . 2008 . Congener-specific numbering systems for the environmentally relevant C4 through C8 perfluorinated homologue groups of alkyl sulfonates, carboxylates, telomer alcohols, olefins, and acids, and their derivatives . Journal of Environmental Science and Health, Part A . en . 43 . 12 . 1391–1401 . 10.1080/10934520802232030.
  15. Buck. Robert C. Franklin. James. Berger. Urs. Conder. Jason M. Cousins. Ian T. de Voogt. Pim. Jensen. Allan Astrup. Kannan. Kurunthachalam. Mabury. Scott A. van Leeuwen. Stefan PJ. 2011. Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins. Integrated Environmental Assessment and Management. 7. 4. 513–541. 10.1002/ieam.258. 3214619. 21793199. 2011IEAM....7..513B .
  16. Book: Lists of PFOS, PFAS, PFCA, related compounds and chemicals that may degrade to PFCA. August 2007. OECD. Annex 1: Perfluorooctane sulfonate (PFOS) and related compounds.
  17. Renner R. Perfluorinated sources outside and inside. Environ. Sci. Technol.. 38 . 5 . 80A . March 2004. 15046317 . 10.1021/es040387w. 2004EnST...38...80R. free.
  18. Lehmler . HJ. Synthesis of environmentally relevant fluorinated surfactants—a review. Chemosphere . 58 . 11 . 1471–96 . March 2005. 10.1016/j.chemosphere.2004.11.078 . 15694468 . 2005Chmsp..58.1471L.
  19. Pelley J . Canada moves to eliminate PFOS stain repellents . Environ. Sci. Technol. . 38 . 23 . 452A . December 2004 . 15597866 . 10.1021/es040676k. free .
  20. 10.1016/j.cej.2017.10.153. Advanced Oxidation/Reduction Processes treatment for aqueous perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) – A review of recent advances. 2018. Trojanowicz. Marek. Bojanowska-Czajka. Anna. Bartosiewicz. Iwona. Kulisa. Krzysztof. Chemical Engineering Journal. 336. 170–199. 2018ChEnJ.336..170T .
  21. Eriksson. Ulrika. Haglund. Peter. Kärrman. Anna. 2017. Contribution of precursor compounds to the release of per- and polyfluoroalkyl substances (PFASs) from waste water treatment plants (WWTPs). Journal of Environmental Sciences (China). 61. 80–90. 10.1016/j.jes.2017.05.004. 29191318. 2017JEnvS..61...80E .
  22. Web site: 2009 . Substance flow analysis for Switzerland . Federal Office for the Environment.
  23. Yang . Renjun . Liu . Shuyu . Liang . Xiaoxing . Yin . Nuoya . Ruan . Ting . Jiang . Linshu . Faiola . Francesco . F–53B and PFOS treatments skew human embryonic stem cell in vitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway . Environmental Pollution . June 2020 . 261 . 114153 . 10.1016/j.envpol.2020.114153 . 32088431 . 2020EPoll.26114153Y . 211260717 . 20 December 2022.
  24. Web site: ATSDR Public Health Statement Perfluoroalkyls .
  25. Renner . Rebecca . PFOS phaseout pays off . Environ. Sci. Technol. . 42 . 13 . 4618 . 2008 . 10.1021/es0871614 . 18677976 . 2008EnST...42.4618R . free.
  26. PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021). 2023. Int J Hyg Environ Health. 247/. D. Richterová, E. Govarts, L. Fábelová, K. Rausová, L. Rodriguez Martin, L. Gilles, et al. doi: 10.1016/j.ijheh.2022.114057.
  27. Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D . Perfluorinated compounds - exposure assessment for the general population in Western countries. Int. J. Hyg. Environ. Health. 212. 3. 239–70. May 2009. 18565792. 10.1016/j.ijheh.2008.04.007. 2009IJHEH.212..239F.
  28. Olsen . Geary W . Church . Timothy R . Miller . John P . Burris . Jean M . Hansen . Kristen J . Lundberg . James K . Armitage . John B . Herron . Ross M . Medhdizadehkashi . Zahra . Nobiletti . John B . O'Neill . E Mary . Mandel . Jeffrey H . Zobel . Larry R . Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. . Environmental Health Perspectives . December 2003 . 111 . 16 . 1892–1901 . 10.1289/ehp.6316 . 14644663 . 1241763 .
  29. Betts KS . July 2008 . Not immune to PFOS effects? . . 116 . 7 . A290 . 10.1289/ehp.116-a290a . 2453185 . 18629339.
  30. Sunderland . Elsie M. . Hu . Xindi C. . Dassuncao . Clifton . Tokranov . Andrea K. . Wagner . Charlotte C. . Allen . Joseph G. . March 2019 . A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects . Journal of Exposure Science & Environmental Epidemiology . 29 . 2 . 131–147 . 10.1038/s41370-018-0094-1 . 1559-064X . 6380916 . 30470793.
  31. Tarapore . Pheruza . Ouyang . Bin . 2021-04-05 . Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility? . International Journal of Environmental Research and Public Health . 18 . 7 . 3794 . 10.3390/ijerph18073794 . 1661-7827 . 8038605 . 33916482. free .
  32. News: LaMotte . Sandee . Locally caught fish are full of dangerous chemicals called PFAS, study finds . 15 February 2023 . CNN . 17 January 2023 . en . 14 February 2023 . https://web.archive.org/web/20230214213701/https://edition.cnn.com/2023/01/17/health/freshwater-fish-pfas-contamination-wellness/index.html . live .
  33. Barbo . Nadia . Stoiber . Tasha . Naidenko . Olga V. . Andrews . David Q. . Locally caught freshwater fish across the United States are likely a significant source of exposure to PFOS and other perfluorinated compounds . Environmental Research . 1 March 2023 . 220 . 115165 . 10.1016/j.envres.2022.115165 . 36584847 . 2023ER....22015165B . 255248441 . en . 0013-9351. free .
  34. Arvaniti . Olga S. . Stasinakis . Athanasios S. . Review on the occurrence, fate and removal of perfluorinated compounds during wastewater treatment . Science of the Total Environment . 15 August 2015 . 524–525 . 81–92 . 10.1016/j.scitotenv.2015.04.023 . 25889547 . 2015ScTEn.524...81A .
  35. Web site: Third Unregulated Contaminant Monitoring Rule. OW. US EPA. September 1, 2015. US EPA.
  36. Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC . Biological monitoring of polyfluoroalkyl substances: A review . . 40 . 11 . 3463–73 . June 2006 . 16786681 . 10.1021/es052580b. 2006EnST...40.3463H . Supporting Information (PDF).
  37. Dauwe . Tom . Van de Vijver . Kristin . De Coen . Wim . Eens . Marcel . April 2007 . PFOS levels in the blood and liver of a small insectivorous songbird near a fluorochemical plant . Environment International . 33 . 3 . 357–361 . 10.1016/j.envint.2006.11.014 . 17188355. 2007EnInt..33..357D .
  38. Saini . Amandeep . Chinnadurai . Sita . Schuster . Jasmin K. . Eng . Anita . Harner . Tom . February 2023 . Per- and polyfluoroalkyl substances and volatile methyl siloxanes in global air: Spatial and temporal trends . Environmental Pollution . 323 . 121291 . 10.1016/j.envpol.2023.121291. 36796663 . 256881039 . free . 2023EPoll.32321291S .
  39. Blake . Bevin E. . Fenton . Suzanne E. . October 2020 . Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects . Toxicology . 443 . 152565 . 10.1016/j.tox.2020.152565 . 1879-3185 . 7530144 . 32861749. 2020Toxgy.44352565B .
  40. OECD . Hazard Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts . ENV/JM/RD(2002)17/FINAL (Page 5) . 2002 . http://web.archive.org/web/20150916064735/https://www.oecd.org/env/ehs/risk-assessment/2382880.pdf . September 16, 2015.
  41. Gao . Xuping . Ni . Wanze . Zhu . Sui . Wu . Yanxin . Cui . Yunfeng . Ma . Junrong . Liu . Yanhua . Qiao . Jinlong . Ye . Yanbin . Yang . Pan . Liu . Chaoqun . October 2021 . Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis . Environmental Research . 201 . 111632 . 10.1016/j.envres.2021.111632 . 1096-0953 . 34237336. 2021ER....20111632G .
  42. Stein . C. R. . Savitz . D. A. . Dougan . M. . Serum Levels of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and Pregnancy Outcome . American Journal of Epidemiology . 19 August 2009 . 170 . 7 . 837–846 . 10.1093/aje/kwp212 . 19692329 . free .
  43. Web site: Health Effects Support Document for Perfluorooctane Sulfonate (PFOS) .
  44. Gao . Xuping . Ni . Wanze . Zhu . Sui . Wu . Yanxin . Cui . Yunfeng . Ma . Junrong . Liu . Yanhua . Qiao . Jinlong . Ye . Yanbin . Yang . Pan . Liu . Chaoqun . October 2021 . Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis . Environmental Research . 201 . 111632 . 10.1016/j.envres.2021.111632 . 1096-0953 . 34237336. 2021ER....201k1632G .
  45. Szilagyi . John T. . Freedman . Anastasia N. . Kepper . Stewart L. . Keshava . Arjun M. . Bangma . Jackie T. . Fry . Rebecca C. . 2020-06-01 . Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro . Toxicological Sciences. 175 . 2 . 210–219 . 10.1093/toxsci/kfaa043 . 1096-0929 . 7253207 . 32219433.
  46. Li . Xiaoheng . Ye . Leping . Ge . Yufei . Yuan . Kaiming . Zhang . Yufei . Liang . Yong . Wei . Jia . Zhao . Connie . Lian . Qing-Quan . Zhu . Xueqiong . Ge . Ren-Shan . March 2016 . In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: A mechanism study . Placenta . 39 . 125–133 . 10.1016/j.placenta.2016.01.010 . 1532-3102 . 26992685.
  47. Ames . Jennifer L. . Windham . Gayle C. . Lyall . Kristen . Pearl . Michelle . Kharrazi . Martin . Yoshida . Cathleen K. . Van de Water . Judy . Ashwood . Paul . Croen . Lisa A. . March 2020 . Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability . Autism Research. 13 . 3 . 444–455 . 10.1002/aur.2247 . 1939-3806 . 31823519. 209316725 .
  48. Moog . N.K. . Entringer . S. . Heim . C. . Wadhwa . P.D. . Kathmann . N. . Buss . C. . February 2017 . Influence of maternal thyroid hormones during gestation on fetal brain development . Neuroscience . 342 . 68–100 . 10.1016/j.neuroscience.2015.09.070 . 26434624 . 4819012 . 0306-4522.
  49. Mogensen . Ulla B. . Grandjean . Philippe . Nielsen . Flemming . Weihe . Pal . Budtz-Jørgensen . Esben . 2015-09-01 . Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates . Environmental Science & Technology . 49 . 17 . 10466–10473 . 10.1021/acs.est.5b02237 . 1520-5851 . 6190571 . 26291735. 2015EnST...4910466M .
  50. Haug . Line S. . Huber . Sandra . Becher . Georg . Thomsen . Cathrine . May 2011 . Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure . Environment International . 37 . 4 . 687–693 . 10.1016/j.envint.2011.01.011 . 1873-6750 . 21334069. 2011EnInt..37..687H . 10852/12717 . free .
  51. Web site: 2021-11-19 . PFAS and Breastfeeding ATSDR . 2022-04-07 . www.atsdr.cdc.gov . en-us.
  52. Coperchini . F. . Awwad . O. . Rotondi . M. . Santini . F. . Imbriani . M. . Chiovato . L. . February 2017 . Thyroid disruption by perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) . Journal of Endocrinological Investigation . 40 . 2 . 105–121 . 10.1007/s40618-016-0572-z . 1720-8386 . 27837466. 207503788 .
  53. Dallaire . Renée . Dewailly . Éric . Pereg . Daria . Dery . Serge . Ayotte . Pierre . Thyroid Function and Plasma Concentrations of Polyhalogenated Compounds in Inuit Adults . Environmental Health Perspectives . September 2009 . 117 . 9 . 1380–1386 . 10.1289/ehp.0900633 . 19750101 . 2737013 .
  54. Coperchini . Francesca . Croce . Laura . Ricci . Gianluca . Magri . Flavia . Rotondi . Mario . Imbriani . Marcello . Chiovato . Luca . 2021 . Thyroid Disrupting Effects of Old and New Generation PFAS . Frontiers in Endocrinology . 11 . 612320 . 10.3389/fendo.2020.612320 . 33542707 . 7851056 . 1664-2392. free .
  55. Boesen . Sophie A. H. . Long . Manhai . Wielsøe . Maria . Mustieles . Vicente . Fernandez . Mariana F. . Bonefeld-Jørgensen . Eva C. . 2020-10-13 . Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review . Environmental Health . 19 . 1 . 107 . 10.1186/s12940-020-00647-1 . 1476-069X . 7557068 . 33050930 . free . 2020EnvHe..19..107B .
  56. Steenland . K. . Tinker . S. . Frisbee . S. . Ducatman . A. . Vaccarino . V. . Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant . American Journal of Epidemiology . 21 October 2009 . 170 . 10 . 1268–1278 . 10.1093/aje/kwp279 . 19846564 . free .
  57. Nelson . Jessica W. . Hatch . Elizabeth E. . Webster . Thomas F. . Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population . Environmental Health Perspectives . February 2010 . 118 . 2 . 197–202 . 10.1289/ehp.0901165 . 20123614 . 2831917 .
  58. Web site: US EPA . OW . 2016-05-05 . Drinking Water Health Advisories for PFOA and PFOS . 2022-03-31 . www.epa.gov . en.
  59. Saikat . Sohel . Kreis . Irene . Davies . Bethan . Bridgman . Stephen . Kamanyire . Robie . February 2013 . The impact of PFOS on health in the general population: a review . Environmental Science: Processes & Impacts . 15 . 2 . 329–335 . 10.1039/c2em30698k . 2050-7895 . 25208696.
  60. Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults . American Journal of Epidemiology . 2011-10-15 . Anoop . Shankar . Jie Xiao . Alan Ducatman . 174 . 8 . 893–900 . 21873601 . 10.1093/aje/kwr171 . 3218627.
  61. Zahm . Shelia . Bonde . Jens Peter . Chiu . Weihsueh A . Hoppin . Jane . Kanno . Jun . Abdallah . Mohamed . Blystone . Chad R . Calkins . Miriam M . Dong . Guang-Hui . Dorman . David C . Fry . Rebecca . Guo . Huan . Haug . Line S . Hofmann . Jonathan N . Iwasaki . Motoki . 2023 . Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid . . 25 . 1 . 16–17 . 10.1016/S1470-2045(23)00622-8. 38043561 .
  62. Web site: 2020-10-15 . PFAS Exposure and Risk of Cancer - National Cancer Institute . 2022-04-14 . dceg.cancer.gov . en.
  63. Peden-Adams . M. M. . Keil . D. E. . Romano . T. . Mollenhauer . M. A. M. . Fort . D. J. . Guiney . P. D. . Houde . M. . Kannan . K. . Muir . D. C. . Rice . C. D. . Stuckey . J. . 2009 . Health effects of perfluorinated compounds—What are the wildlife telling us? . Reproductive Toxicology . 27 . 3–4 . 414–415 . 10.1016/j.reprotox.2008.11.016 . J. M. . Keller . P. A. . Fair . Talent . G. D. . Bossart . T. . Segars . A. L. . L. . Scott. 2009RepTx..27..414P .
  64. Peden-Adams et al. (June 2008). In PFAA Days II (PDF). p. 28.
  65. Peden-Adams . M. . Stuckey . J. . Gaworecki . K. . Berger-Ritchie . J. . Bryant . K. . Jodice . P. . Scott . T. . Ferrario . J. . Guan . B. . Vigo . C. . Boone . J. S. . 2009 . Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS) . Reproductive Toxicology (Elmsford, N.Y.) . 27 . 3–4 . 307–318 . 10.1016/j.reprotox.2008.10.009 . 19071210 . Dewitt . W. D. . McGuinn . J. C. . D. E. . Keil. 2009RepTx..27..307P .
  66. http://www.pops.int/Portals/0/download.aspx?d=UNEP-POPS-COP.4-SC-4-17.English.pdf SC-4/17: Listing of perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride
  67. http://www.pops.int/Portals/0/download.aspx?d=UNEP-POPS-COP.9-SC-9-4.English.pdf SC-9/4: Perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride
  68. SCHER. RPA's report "Perfluorooctane Sulphonates Risk reduction strategy and analysis of advantages and drawbacks" . Scientific Committee on Health and Environmental Risks, European Commission . 2005 .
  69. Web site: DIRECTIVE 2006/122/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 12 December 2006.
  70. Web site: COMMISSION REGULATION (EC) No 552/2009 of 22 June 2009.
  71. Web site: COMMISSION REGULATION (EU) No 757/2010 of 24 August 2010.
  72. Web site: 2018-01-10 . Michigan abruptly sets PFAS cleanup rules . 2022-03-27 . mlive . en.
  73. Web site: Matheny . Keith . 3 August 2020 . Michigan's drinking water standards for these chemicals now among toughest in nation . live . https://web.archive.org/web/20220131152306/https://eu.freep.com/story/news/local/michigan/2020/08/03/tougher-pfas-standards-drinking-water-michigan/5574268002/ . 31 January 2022 . 31 March 2022 . Detroit Free Press.
  74. Web site: 3 August 2020 . New state drinking water standards pave way for expansion of Michigan's PFAS clean-up efforts . live . https://web.archive.org/web/20220103083526/https://www.michigan.gov/egle/0,9429,7-135--535602--,00.html . 3 January 2022 . 6 April 2022 . Michigan.gov.
  75. Web site: Assembly Bill No. 2762 . State of California . 10 October 2020 . September 30, 2020.
  76. EPA (2021-03-03). "Announcement of Final Regulatory Determinations for Contaminants on the Fourth Drinking Water Contaminant Candidate List." Federal Register,
  77. RIN 2050-AH09
  78. Docket EPA-HQ-OLEM-2019-0341

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