Perflubron Explained

Perflubron (INN/USAN, or perfluorooctyl bromide; brand name Imagent) is a contrast medium for magnetic resonance imaging, computer tomography and sonography.^[1] It was approved for this use in the United States by the Food and Drug Administration in 1993.^[2]

Experimental research

Perflubron has also been tested experimentally for use in liquid breathing in premature infants with respiratory distress.^{[3] [4]}

Notes and References

1. Mattrey RF . Perfluorooctylbromide: a new contrast agent for CT, sonography, and MR imaging . AJR. American Journal of Roentgenology . 152 . 2 . 247–52 . February 1989 . 2643258 . 10.2214/ajr.152.2.247 .
2. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.DrugDetails FDA Approved Drug Products
3. Wolfson MR, Kechner NE, Roache RF, DeChadarevian JP, Friss HE, Rubenstein SD, Shaffer TH . Perfluorochemical rescue after surfactant treatment: effect of perflubron dose and ventilatory frequency . Journal of Applied Physiology . 84 . 2 . 624–40 . February 1998 . 9475875 . 10.1152/jappl.1998.84.2.624 .
4. Leach CL, Greenspan JS, Rubenstein SD, Shaffer TH, Wolfson MR, Jackson JC, DeLemos R, Fuhrman BP . 6 . Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. The LiquiVent Study Group . The New England Journal of Medicine . 335 . 11 . 761–7 . September 1996 . 8778584 . 10.1056/NEJM199609123351101 . free .