| Peršėkė | |
| Mouth: | Neman |
| Mouth Coordinates: | 54.5292°N 23.8922°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Lithuania |
| Subdivision Type2: | Location |
| Subdivision Name2: | Alytus district municipality, Alytus County |
| Length: | 66km (41miles) |
| Discharge1 Avg: | 3.6m3/s |
| Basin Size: | 542km2 |
| Tributaries Left: | Metelytė, Atesė, Gluosinė, Varputys, Rudė, Kamaria, Vaičiukupis |
| Tributaries Right: | Paežerėlė, Rudė II, Dūmė |
The Peršėkė is a river of Alytus district municipality, Alytus County, southern Lithuania. It flows for 66 kilometres and has a basin area of 542 km².
It begins near Gervėnai village and crosses the Lake Obelija at upper course. There is a water reservoir on Peršėkė near Krokialaukis. The most important settlements along the Peršekė are Krokialaukis and Balbieriškis. Peršėkė joins the river Neman from its left side.