Peptidoglycolipid addressing protein explained

The Peptidoglycolipid Addressing Protein (GAP) Family^[1] is a member of the Lysine Exporter (LysE) Superfamily.^[2] It is listed as item 2.A.116 in the Transporter Classification Database. The mechanism of its action is not known, but this family has been shown to be a member of the LsyE superfamily. Therefore, these proteins are most likely secondary carriers.

The proposed generalized reaction catalyzed by members of the GAP family is:

PGL (in) → PGL (outer membrane).

See also

• Transport Protein
• Glycolipid

Further reading

• Tsu, Brian V.; Saier, Milton H. "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE 10 (10).doi:10.1371/journal.pone.0137184. PMC 4608589.PMID 26474485.
• Seeliger, Jessica C.; Holsclaw, Cynthia M.; Schelle, Michael W.; Botyanszki, Zsofia; Gilmore, Sarah A.; Tully, Sarah E.; Niederweis, Michael; Cravatt, Benjamin F.; Leary, Julie A. (2012-03-09). "Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis". Journal of Biological Chemistry 287 (11): 7990–8000. doi:10.1074/jbc.M111.315473. ISSN 0021-9258. PMC 3318749. PMID 22194604.

Notes and References

1. Sondén. Berit. Kocíncová. Dana. Deshayes. Caroline. Euphrasie. Daniel. Rhayat. Lamya. Laval. Françoise. Frehel. Claude. Daffé. Mamadou. Etienne. Gilles. 2005-10-01. Gap, a mycobacterial specific integral membrane protein, is required for glycolipid transport to the cell surface. Molecular Microbiology. 58. 2. 426–440. 10.1111/j.1365-2958.2005.04847.x. 0950-382X. 16194230. 25144966.
2. Tsu. Brian V.. Saier. Milton H.. 2015-01-01. The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. PLOS ONE. 10. 10. e0137184. 10.1371/journal.pone.0137184. 1932-6203. 4608589. 26474485. 2015PLoSO..1037184T. free.