Peptide-methionine (S)-S-oxide reductase explained

Peptide-methionine (S)-S-oxide reductase
Ec Number:	1.8.4.11

Peptide-methionine (S)-S-oxide reductase (MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase, formerly protein-methionine-S-oxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming).^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10]} This enzyme catalyses the following chemical reaction

(1) peptide-L-methionine + thioredoxin disulfide + H₂O

\rightleftharpoons peptide-L-methionine (S)-S-oxide + thioredoxin

(2) L-methionine + thioredoxin disulfide + H₂O

\rightleftharpoons L-methionine (S)-S-oxide + thioredoxin

The reaction occurs in the reverse direction.

Notes and References

1. Moskovitz J, Singh VK, Requena J, Wilkinson BJ, Jayaswal RK, Stadtman ER . Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity . Biochemical and Biophysical Research Communications . 290 . 1 . 62–5 . January 2002 . 11779133 . 10.1006/bbrc.2001.6171 .
2. Taylor AB, Benglis DM, Dhandayuthapani S, Hart PJ . Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine . Journal of Bacteriology . 185 . 14 . 4119–26 . July 2003 . 12837786 . 164888 . 10.1128/JB.185.14.4119-4126.2003 .
3. Singh VK, Moskovitz J . Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress . Microbiology . 149 . Pt 10 . 2739–47 . October 2003 . 14523107 . 10.1099/mic.0.26442-0 . free .
4. Boschi-Muller S, Olry A, Antoine M, Branlant G . The enzymology and biochemistry of methionine sulfoxide reductases . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1703 . 2 . 231–8 . January 2005 . 15680231 . 10.1016/j.bbapap.2004.09.016 .
5. Ezraty B, Aussel L, Barras F . Methionine sulfoxide reductases in prokaryotes . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1703 . 2 . 221–9 . January 2005 . 15680230 . 10.1016/j.bbapap.2004.08.017 .
6. Weissbach H, Resnick L, Brot N . Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1703 . 2 . 203–12 . January 2005 . 15680228 . 10.1016/j.bbapap.2004.10.004 .
7. Kauffmann B, Aubry A, Favier F . The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1703 . 2 . 249–60 . January 2005 . 15680233 . 10.1016/j.bbapap.2004.09.008 .
8. Vougier S, Mary J, Friguet B . Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells . The Biochemical Journal . 373 . Pt 2 . 531–7 . July 2003 . 12693988 . 1223498 . 10.1042/BJ20030443 .
9. Olry A, Boschi-Muller S, Marraud M, Sanglier-Cianferani S, Van Dorsselear A, Branlant G . Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis . The Journal of Biological Chemistry . 277 . 14 . 12016–22 . April 2002 . 11812798 . 10.1074/jbc.M112350200 . free .
10. Brot N, Weissbach L, Werth J, Weissbach H . Enzymatic reduction of protein-bound methionine sulfoxide . Proceedings of the National Academy of Sciences of the United States of America . 78 . 4 . 2155–8 . April 1981 . 7017726 . 319302 . 10.1073/pnas.78.4.2155 . free .