| Pepper Creek | |
| Map Size: | 180 |
| Map Alt: | Map of the mouth of Pepper Creek |
| Pushpin Map: | Delaware#USA |
| Pushpin Map Size: | 180 |
| Pushpin Map Alt: | Location of the mouth of Pepper Creek |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Delaware |
| Subdivision Type3: | County |
| Subdivision Name3: | Sussex |
| Subdivision Type4: | City |
| Subdivision Name4: | Frankford |
| Source1: | On the watershed divide between Pepper Creek and Pocomoke River |
| Source1 Location: | Frankford, Delaware |
| Source1 Coordinates: | 38.5353°N -75.2872°W[1] |
| Source1 Elevation: | about 40 feet amsl |
| Mouth: | just south of Oak Orchard, Delaware |
| Mouth Location: | Clarksville, Delaware |
| Mouth Coordinates: | 38.5878°N -75.1675°W |
| Mouth Elevation: | sea level (0 ft.) |
| Progression: | northeast |
| River System: | Indian River |
Pepper Creek is a stream approximately 8 mi (13 km) long in southern Delaware in the United States.
It rises in Cypress Swamp in southern Sussex County, approximately 3 mi (5 km) north of the Maryland state line. It flows generally east-northeast, past Dagsboro and into Indian River Bay, an inlet of the Atlantic Ocean, approximately 2 mi (3 km) northwest of Millville.
The upper course of the creek is connected by channelized ditches through Cypress Swamp to the headwaters of the Pocomoke River.