Pentanoyl chloride explained

Pentanoyl chloride is an acyl chloride derived from pentanoic acid. It is a colorless liquid that is used to attach the valeroyl group. It is usually produced by chlorination of valeric acid.[1]

Reactions

Like related acyl chlorides, valeryl chloride hydrolyzes readily:

CH3(CH2)3C(O)Cl + H2O → CH3(CH2)3CO2H + HClAlcohols react to give esters:

CH3(CH2)3C(O)Cl + ROH → CH3(CH2)3CO2R + HClAmines react to give amides:

CH3(CH2)3C(O)Cl + R2NH → CH3(CH2)3C(O)NR2 + HClBenzene reacts under conditions of the Friedel-Crafts reaction to give valerophenone:

CH3(CH2)3C(O)Cl + C6H6 → CH3(CH2)3C(O)C6H5 + HCl

Notes and References

  1. n-Butyryl Chloride. B. . Helferich. W.. Schaefer. Org. Synth. . 1929. 9. 32. 10.15227/orgsyn.009.0032.